Detection and Typing of Human Papillomavirus DNA in Benign and Malignant Tumours of Laryngeal Epithelium

The role of human papillomaviruses (HPV) in laryngeal squamous cell carcinoma has not yet been established. Thirty-three cases of laryngeal squamous cell carcinoma were analysed for the presence of HPV DNA and compared with 25 cases of normal larynx and 29 cases of laryngeal squamous papilloma in th...

Full description

Saved in:
Bibliographic Details
Published in:Acta oto-laryngologica 1998, Vol.118 (5), p.754-758
Main Authors: R, Garcia-Milian, H, Hernandez, L, Panade, C, Rodriguez, N, Gonzalez, C, Valenzuela, M d J, Arana, E, Perea S
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Base Sequence
Biological and medical sciences
Biopsy
Blotting, Southern - methods
Blotting, Southern - statistics & numerical data
Carcinoma, Squamous Cell - etiology
Carcinoma, Squamous Cell - virology
Chi-Square Distribution
DNA Primers
DNA, Viral - analysis
DNA, Viral - genetics
Epithelium - pathology
Epithelium - virology
Human papillomavirus
Humans
Laryngeal Neoplasms - etiology
Laryngeal Neoplasms - virology
Larynx - pathology
Larynx - virology
Medical sciences
Middle Aged
Molecular Sequence Data
Otorhinolaryngology. Stomatology
Papilloma - etiology
Papilloma - virology
Papillomaviridae - genetics
Papillomavirus Infections - etiology
Papillomavirus Infections - virology
Polymerase Chain Reaction - methods
Polymerase Chain Reaction - statistics & numerical data
Tumor Virus Infections - etiology
Tumor Virus Infections - virology
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The role of human papillomaviruses (HPV) in laryngeal squamous cell carcinoma has not yet been established. Thirty-three cases of laryngeal squamous cell carcinoma were analysed for the presence of HPV DNA and compared with 25 cases of normal larynx and 29 cases of laryngeal squamous papilloma in their positivity index. The presence of HPV DNA was analysed by using L1 consensus primers and also by primers specific for the E7 gene of HPV types 16 and 18. Four normal laryngeal samples (16%) were positive for HPV DNA against the 24 samples (82%) (p
ISSN:0001-6489
1651-2251
DOI:10.1080/00016489850183313