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Detection and Typing of Human Papillomavirus DNA in Benign and Malignant Tumours of Laryngeal Epithelium
The role of human papillomaviruses (HPV) in laryngeal squamous cell carcinoma has not yet been established. Thirty-three cases of laryngeal squamous cell carcinoma were analysed for the presence of HPV DNA and compared with 25 cases of normal larynx and 29 cases of laryngeal squamous papilloma in th...
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| Published in: | Acta oto-laryngologica 1998, Vol.118 (5), p.754-758 |
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| Main Authors: | , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c461t-10f7bdee1377f80a7b12a7f32f451faafdea0cbacb2071a6a643e01a9a58fc433 |
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| container_issue | 5 |
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| container_title | Acta oto-laryngologica |
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| creator | R, Garcia-Milian H, Hernandez L, Panade C, Rodriguez N, Gonzalez C, Valenzuela M d J, Arana E, Perea S |
| description | The role of human papillomaviruses (HPV) in laryngeal squamous cell carcinoma has not yet been established. Thirty-three cases of laryngeal squamous cell carcinoma were analysed for the presence of HPV DNA and compared with 25 cases of normal larynx and 29 cases of laryngeal squamous papilloma in their positivity index. The presence of HPV DNA was analysed by using L1 consensus primers and also by primers specific for the E7 gene of HPV types 16 and 18. Four normal laryngeal samples (16%) were positive for HPV DNA against the 24 samples (82%) (p |
| doi_str_mv | 10.1080/00016489850183313 |
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Thirty-three cases of laryngeal squamous cell carcinoma were analysed for the presence of HPV DNA and compared with 25 cases of normal larynx and 29 cases of laryngeal squamous papilloma in their positivity index. The presence of HPV DNA was analysed by using L1 consensus primers and also by primers specific for the E7 gene of HPV types 16 and 18. Four normal laryngeal samples (16%) were positive for HPV DNA against the 24 samples (82%) (p<0.001) found for laryngeal papilloma and 16 (48.5%) (p<0.05) found for laryngeal squamous cell carcinoma. HPV 16 was the type most frequently found in laryngeal carcinoma samples. Our results support an etiologic role for this type of HPV in the pathogenesis of laryngeal carcinoma.</description><identifier>ISSN: 0001-6489</identifier><identifier>EISSN: 1651-2251</identifier><identifier>DOI: 10.1080/00016489850183313</identifier><identifier>PMID: 9840518</identifier><identifier>CODEN: AOLAAJ</identifier><language>eng</language><publisher>Stockholm: Informa UK Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Base Sequence ; Biological and medical sciences ; Biopsy ; Blotting, Southern - methods ; Blotting, Southern - statistics & numerical data ; Carcinoma, Squamous Cell - etiology ; Carcinoma, Squamous Cell - virology ; Chi-Square Distribution ; DNA Primers ; DNA, Viral - analysis ; DNA, Viral - genetics ; Epithelium - pathology ; Epithelium - virology ; Human papillomavirus ; Humans ; Laryngeal Neoplasms - etiology ; Laryngeal Neoplasms - virology ; Larynx - pathology ; Larynx - virology ; Medical sciences ; Middle Aged ; Molecular Sequence Data ; Otorhinolaryngology. Stomatology ; Papilloma - etiology ; Papilloma - virology ; Papillomaviridae - genetics ; Papillomavirus Infections - etiology ; Papillomavirus Infections - virology ; Polymerase Chain Reaction - methods ; Polymerase Chain Reaction - statistics & numerical data ; Tumor Virus Infections - etiology ; Tumor Virus Infections - virology ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Acta oto-laryngologica, 1998, Vol.118 (5), p.754-758</ispartof><rights>1998 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-10f7bdee1377f80a7b12a7f32f451faafdea0cbacb2071a6a643e01a9a58fc433</citedby><cites>FETCH-LOGICAL-c461t-10f7bdee1377f80a7b12a7f32f451faafdea0cbacb2071a6a643e01a9a58fc433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2430528$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9840518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>R, Garcia-Milian</creatorcontrib><creatorcontrib>H, Hernandez</creatorcontrib><creatorcontrib>L, Panade</creatorcontrib><creatorcontrib>C, Rodriguez</creatorcontrib><creatorcontrib>N, Gonzalez</creatorcontrib><creatorcontrib>C, Valenzuela</creatorcontrib><creatorcontrib>M d J, Arana</creatorcontrib><creatorcontrib>E, Perea S</creatorcontrib><title>Detection and Typing of Human Papillomavirus DNA in Benign and Malignant Tumours of Laryngeal Epithelium</title><title>Acta oto-laryngologica</title><addtitle>Acta Otolaryngol</addtitle><description>The role of human papillomaviruses (HPV) in laryngeal squamous cell carcinoma has not yet been established. Thirty-three cases of laryngeal squamous cell carcinoma were analysed for the presence of HPV DNA and compared with 25 cases of normal larynx and 29 cases of laryngeal squamous papilloma in their positivity index. The presence of HPV DNA was analysed by using L1 consensus primers and also by primers specific for the E7 gene of HPV types 16 and 18. Four normal laryngeal samples (16%) were positive for HPV DNA against the 24 samples (82%) (p<0.001) found for laryngeal papilloma and 16 (48.5%) (p<0.05) found for laryngeal squamous cell carcinoma. HPV 16 was the type most frequently found in laryngeal carcinoma samples. Our results support an etiologic role for this type of HPV in the pathogenesis of laryngeal carcinoma.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Blotting, Southern - methods</subject><subject>Blotting, Southern - statistics & numerical data</subject><subject>Carcinoma, Squamous Cell - etiology</subject><subject>Carcinoma, Squamous Cell - virology</subject><subject>Chi-Square Distribution</subject><subject>DNA Primers</subject><subject>DNA, Viral - analysis</subject><subject>DNA, Viral - genetics</subject><subject>Epithelium - pathology</subject><subject>Epithelium - virology</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Laryngeal Neoplasms - etiology</subject><subject>Laryngeal Neoplasms - virology</subject><subject>Larynx - pathology</subject><subject>Larynx - virology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Papilloma - etiology</subject><subject>Papilloma - virology</subject><subject>Papillomaviridae - genetics</subject><subject>Papillomavirus Infections - etiology</subject><subject>Papillomavirus Infections - virology</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Polymerase Chain Reaction - statistics & numerical data</subject><subject>Tumor Virus Infections - etiology</subject><subject>Tumor Virus Infections - virology</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0001-6489</issn><issn>1651-2251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi1EVZbCD-CA5APqLeCx43wILqUttNLycVjO0cSxd105drCTov33JNqlEkIqJ9ua5xnN-CXkFbC3wCr2jjEGRV7VlWRQCQHiCVlBISHjXMJTslrq2QI8I89TulueM3tKTusqZxKqFdld6VGr0QZP0Xd0sx-s39Jg6M3Uo6ffcbDOhR7vbZwSvfp6Qa2nH7W324PwBd18RT_SzdSHKabFXWPc-61GR68HO-60s1P_gpwYdEm_PJ5n5Men683lTbb-9vn28mKdqbyAMQNmyrbTGkRZmoph2QLH0ghucgkG0XQamWpRtZyVgAUWudAMsEZZGZULcUbOD32HGH5OOo1Nb5PSzqHXYUpNyVjNhcj_C3JWS8lhAeEAqhhSito0Q7T9vGIDrFliaP6JYXZeH5tPba-7B-P473P9zbGOSaEzEb2y6QHjuWCSL9iHA2a9CbHHXyG6rhlx70L844jHpnj_l76bIxl3CqNu7uas_JzDIzv8Bl1TtNA</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>R, Garcia-Milian</creator><creator>H, Hernandez</creator><creator>L, Panade</creator><creator>C, Rodriguez</creator><creator>N, Gonzalez</creator><creator>C, Valenzuela</creator><creator>M d J, Arana</creator><creator>E, Perea S</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor and Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>1998</creationdate><title>Detection and Typing of Human Papillomavirus DNA in Benign and Malignant Tumours of Laryngeal Epithelium</title><author>R, Garcia-Milian ; H, Hernandez ; L, Panade ; C, Rodriguez ; N, Gonzalez ; C, Valenzuela ; M d J, Arana ; E, Perea S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-10f7bdee1377f80a7b12a7f32f451faafdea0cbacb2071a6a643e01a9a58fc433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Blotting, Southern - methods</topic><topic>Blotting, Southern - statistics & numerical data</topic><topic>Carcinoma, Squamous Cell - etiology</topic><topic>Carcinoma, Squamous Cell - virology</topic><topic>Chi-Square Distribution</topic><topic>DNA Primers</topic><topic>DNA, Viral - analysis</topic><topic>DNA, Viral - genetics</topic><topic>Epithelium - pathology</topic><topic>Epithelium - virology</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Laryngeal Neoplasms - etiology</topic><topic>Laryngeal Neoplasms - virology</topic><topic>Larynx - pathology</topic><topic>Larynx - virology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Papilloma - etiology</topic><topic>Papilloma - virology</topic><topic>Papillomaviridae - genetics</topic><topic>Papillomavirus Infections - etiology</topic><topic>Papillomavirus Infections - virology</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Polymerase Chain Reaction - statistics & numerical data</topic><topic>Tumor Virus Infections - etiology</topic><topic>Tumor Virus Infections - virology</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>R, Garcia-Milian</creatorcontrib><creatorcontrib>H, Hernandez</creatorcontrib><creatorcontrib>L, Panade</creatorcontrib><creatorcontrib>C, Rodriguez</creatorcontrib><creatorcontrib>N, Gonzalez</creatorcontrib><creatorcontrib>C, Valenzuela</creatorcontrib><creatorcontrib>M d J, Arana</creatorcontrib><creatorcontrib>E, Perea S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Acta oto-laryngologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>R, Garcia-Milian</au><au>H, Hernandez</au><au>L, Panade</au><au>C, Rodriguez</au><au>N, Gonzalez</au><au>C, Valenzuela</au><au>M d J, Arana</au><au>E, Perea S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection and Typing of Human Papillomavirus DNA in Benign and Malignant Tumours of Laryngeal Epithelium</atitle><jtitle>Acta oto-laryngologica</jtitle><addtitle>Acta Otolaryngol</addtitle><date>1998</date><risdate>1998</risdate><volume>118</volume><issue>5</issue><spage>754</spage><epage>758</epage><pages>754-758</pages><issn>0001-6489</issn><eissn>1651-2251</eissn><coden>AOLAAJ</coden><abstract>The role of human papillomaviruses (HPV) in laryngeal squamous cell carcinoma has not yet been established. Thirty-three cases of laryngeal squamous cell carcinoma were analysed for the presence of HPV DNA and compared with 25 cases of normal larynx and 29 cases of laryngeal squamous papilloma in their positivity index. The presence of HPV DNA was analysed by using L1 consensus primers and also by primers specific for the E7 gene of HPV types 16 and 18. Four normal laryngeal samples (16%) were positive for HPV DNA against the 24 samples (82%) (p<0.001) found for laryngeal papilloma and 16 (48.5%) (p<0.05) found for laryngeal squamous cell carcinoma. HPV 16 was the type most frequently found in laryngeal carcinoma samples. Our results support an etiologic role for this type of HPV in the pathogenesis of laryngeal carcinoma.</abstract><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>9840518</pmid><doi>10.1080/00016489850183313</doi><tpages>5</tpages></addata></record> |
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| ispartof | Acta oto-laryngologica, 1998, Vol.118 (5), p.754-758 |
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| language | eng |
| recordid | cdi_informahealthcare_journals_10_1080_00016489850183313 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Adult Aged Aged, 80 and over Base Sequence Biological and medical sciences Biopsy Blotting, Southern - methods Blotting, Southern - statistics & numerical data Carcinoma, Squamous Cell - etiology Carcinoma, Squamous Cell - virology Chi-Square Distribution DNA Primers DNA, Viral - analysis DNA, Viral - genetics Epithelium - pathology Epithelium - virology Human papillomavirus Humans Laryngeal Neoplasms - etiology Laryngeal Neoplasms - virology Larynx - pathology Larynx - virology Medical sciences Middle Aged Molecular Sequence Data Otorhinolaryngology. Stomatology Papilloma - etiology Papilloma - virology Papillomaviridae - genetics Papillomavirus Infections - etiology Papillomavirus Infections - virology Polymerase Chain Reaction - methods Polymerase Chain Reaction - statistics & numerical data Tumor Virus Infections - etiology Tumor Virus Infections - virology Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Detection and Typing of Human Papillomavirus DNA in Benign and Malignant Tumours of Laryngeal Epithelium |
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