Eradication of Helicobacter pylori Restores the Inhibitory Effect of Cholecystokinin on Gastric Motility in Duodenal Ulcer Patients

Background: Increased gastric emptying and defective action of endogenous cholecystokinin (CCK), that is known to inhibit this emptying, have been implicated in the pathogenesis of duodenal ulcer (DU). The aim of this double blind study was to assess whether CCK and somatostatin participate in the i...

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 2001, Vol.36 (3), p.241-246
Main Author: J. W. Konturek, R. Stoll, J. Menzel, M. Konturek, S. J. Konturek, W. Domschke
Format: Article
Language:English
Subjects:
Cholecystokinin Cholecystokinin Receptors Gastric Emptying Helicobacter Pylori Somatostatin
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Summary:Background: Increased gastric emptying and defective action of endogenous cholecystokinin (CCK), that is known to inhibit this emptying, have been implicated in the pathogenesis of duodenal ulcer (DU). The aim of this double blind study was to assess whether CCK and somatostatin participate in the impairment of gastric motility in active DU patients before and after Helicobacter pylori eradication. Methods: Tests were undertaken in 10 DU patients without or with elimination of the action of endogenous CCK using loxiglumide, a selective CCK-A receptor antagonist, before and 4 weeks after eradication of H. pylori with 1 week triple therapy that resulted in healing of all DUs tested. The gastric emptying rate after feeding was determined using the 13C-acetate breath test. Before each test, samples of gastric juice were obtained by aspiration using a nasogastric tube for determination of somatostatin using specific radioimmunoassay. Results: Prior to H. pylori
ISSN:0036-5521
1502-7708
DOI:10.1080/00365520119512