Linezolid for the Treatment of Central Nervous System Infections in Neurosurgical Patients

We report our experience with linezolid in the treatment of 5 patients with central nervous system infections subsequent to neurosurgical interventions. In all cases, initial antimicrobial treatment regimens, including a glycopeptide, either failed or were associated with significant adverse events....

Full description

Saved in:
Bibliographic Details
Published in:Scandinavian journal of infectious diseases 2002, Vol.34 (6), p.456-459
Main Authors: Viale, Pierluigi, Pagani, Leonardo, Cristini, Francesco, Stefini, Roberto, Bergomi, Riccardo, Colombini, Paolo, Carosi, Giampiero
Format: Article
Language:English
Subjects:
Acetamides - adverse effects
Acetamides - therapeutic use
Adult
Aged
Anti-Infective Agents - adverse effects
Anti-Infective Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial diseases
Bacterial diseases of the nervous system. Bacterial myositis
Biological and medical sciences
Central Nervous System Diseases - drug therapy
Central Nervous System Diseases - surgery
Fatal Outcome
Human bacterial diseases
Humans
Infectious diseases
Italy
Linezolid
Medical sciences
Middle Aged
Oxazolidinones - adverse effects
Oxazolidinones - therapeutic use
Pharmacology. Drug treatments
Postoperative Complications - drug therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report our experience with linezolid in the treatment of 5 patients with central nervous system infections subsequent to neurosurgical interventions. In all cases, initial antimicrobial treatment regimens, including a glycopeptide, either failed or were associated with significant adverse events. The good clinical outcome and the absence of significant side-effects associated with linezolid suggest that it may be an attractive alternative for the treatment of central nervous system infections, particularly in settings characterized by a high incidence of multiresistant Gram-positive pathogens.
ISSN:0036-5548
1651-1980
DOI:10.1080/00365540110080467