The effect of sublingual misoprostol versus intravenous oxytocin in reducing bleeding after caesarean section

Summary In this study, 100 singleton pregnant women underwent a caesarean delivery under general anaesthesia and were studied in terms of postpartum bleeding using oxytocin or misoprostol. Patients were randomly divided into two equal groups. One group received two tabs of misoprostol 200 μg subling...

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Bibliographic Details
Published in:Journal of obstetrics and gynaecology 2009-01, Vol.29 (7), p.633-636
Main Authors: Eftekhari, N., Doroodian, M., Lashkarizadeh, R.
Format: Article
Language:English
Subjects:
Administration, Sublingual
Adult
Caesarean
Cesarean section
Cesarean Section - adverse effects
Comparative analysis
drug side-effects
Effects
Female
Gynecology
Hemorrhage
Hemostasis, Surgical
Humans
Infusions, Intravenous
misoprostol
Misoprostol - administration & dosage
Obstetrics
Oxytocics - administration & dosage
oxytocin
Oxytocin - administration & dosage
Postoperative Hemorrhage - prevention & control
postpartum haemorrhage
Pregnancy
Women
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Summary:Summary In this study, 100 singleton pregnant women underwent a caesarean delivery under general anaesthesia and were studied in terms of postpartum bleeding using oxytocin or misoprostol. Patients were randomly divided into two equal groups. One group received two tabs of misoprostol 200 μg sublingually and the second group took intravenous infusion of 20 units of oxytocin at the rate of 10 cc/min immediately after delivery until full contraction of the uterine. The amount of blood loss was lower in misoprostol group comparing with oxytocin group (608.91 ml vs 673.9 ml) (p = 0.048) and this difference was statistically significant. The need to give additional oxytocin therapy in oxytocin group (36%) was significantly higher than misoprostol group (14%) (p = 0.032). It seems that the efficacy of sublingual misoprostol is equivalent to that of low dose intravenous oxytocin in reducing postpartum haemorrhage at caesarean section. Misoprostol has some other advantages like long shelf -life, stability at room temperature and oral use.
ISSN:0144-3615
1364-6893
DOI:10.1080/01443610903061744