The effect of sublingual misoprostol versus intravenous oxytocin in reducing bleeding after caesarean section

• Published in: Journal of obstetrics and gynaecology 2009-01, Vol.29 (7), p.633-636
• Main Authors: Eftekhari, N., Doroodian, M., Lashkarizadeh, R.
• Format: Article
• Language: English
• Subjects: Administration, Sublingual; Adult; Caesarean; Cesarean section; Cesarean Section - adverse effects; Comparative analysis; drug side-effects; Effects; Female; Gynecology; Hemorrhage; Hemostasis, Surgical; Humans; Infusions, Intravenous; misoprostol; Misoprostol - administration & dosage; Obstetrics; Oxytocics - administration & dosage; oxytocin; Oxytocin - administration & dosage; Postoperative Hemorrhage - prevention & control; postpartum haemorrhage; Pregnancy; Women
• ISSN: 0144-3615; 1364-6893
• DOI: 10.1080/01443610903061744

Summary In this study, 100 singleton pregnant women underwent a caesarean delivery under general anaesthesia and were studied in terms of postpartum bleeding using oxytocin or misoprostol. Patients were randomly divided into two equal groups. One group received two tabs of misoprostol 200 μg sublingually and the second group took intravenous infusion of 20 units of oxytocin at the rate of 10 cc/min immediately after delivery until full contraction of the uterine. The amount of blood loss was lower in misoprostol group comparing with oxytocin group (608.91 ml vs 673.9 ml) (p = 0.048) and this difference was statistically significant. The need to give additional oxytocin therapy in oxytocin group (36%) was significantly higher than misoprostol group (14%) (p = 0.032). It seems that the efficacy of sublingual misoprostol is equivalent to that of low dose intravenous oxytocin in reducing postpartum haemorrhage at caesarean section. Misoprostol has some other advantages like long shelf -life, stability at room temperature and oral use.