Parameters assessing neurological status in malignant glioma patients: prognostic value for survival and relapse-free time

Malignant gliomas are the commonest primary brain tumours in adults and harbour a dismal prognosis. So far, established parameters with predictive significance for prognosis do not include the neurological functional assessment of patients. The aim of this study was to investigate the prognostic val...

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Bibliographic Details
Published in:British journal of neurosurgery 2008-08, Vol.22 (4), p.557-562
Main Authors: Martinez, R., Völter, C., Behr, R.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Biopsy - methods
Brain cancer
Brain Neoplasms - mortality
Brain Neoplasms - radiotherapy
Brain Neoplasms - surgery
Clinical outcomes
Combined Modality Therapy
Female
Functional
Glioma - mortality
Glioma - radiotherapy
Glioma - surgery
Humans
Karnofsky Performance Status
Male
malignant glioma
Medical treatment
Middle Aged
Nervous System Diseases - diagnosis
Nervous System Diseases - therapy
Neurologic Examination - methods
neurological
Neurosurgery
outcome
Prognosis
Risk Factors
Secondary Prevention
survival
Survival Analysis
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Summary:Malignant gliomas are the commonest primary brain tumours in adults and harbour a dismal prognosis. So far, established parameters with predictive significance for prognosis do not include the neurological functional assessment of patients. The aim of this study was to investigate the prognostic value of parameters assessing neurological status in malignant glioma patients for outcome and survival. Evaluation of neurological status included the Sawaya Functional Grade (SFG) and the Neurological Performance Scale (NPS). Moreover, the Karnofsky Performance Status (KPS), medical risk factors, extension of resection, postoperative complications, and the predictive value of these variables for outcome and survival were studied. For this purpose, we have analysed 110 consecutive patients with malignant gliomas who were treated at our institution. As expected, age (p
ISSN:0268-8697
1360-046X
DOI:10.1080/02688690802166424