The Use of Oscillometry as a Measure of Airway Responsiveness in Asthmatic Children After Histamine and Methacholine Bronchoprovocation with Dosimeter-MedicAid and DeVilbiss Nebulizers

To explore the use of oscillometry as a measure of airway responsiveness, 69 asthmatic children underwent histamine and methacholine bronchoprovocation using dosimeter-MedicAid (Jaeger Co.; Germany) and DeVilbiss nebulizers (DeVilbiss, Bornemouth; England). The mean increase in R5 resistance in chal...

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Bibliographic Details
Published in:The Journal of asthma 2007-01, Vol.44 (4), p.267-271
Main Authors: Kop iva, F., Szotkowská, J., Plocová, A., Závodská, J., Zápalka, M., Smatanová, D., Látalová, M., Slezáková, L., Radová, L.
Format: Article
Language:English
Subjects:
Adolescent
airway hyperresposiveness
asthma
Asthma - diagnosis
Asthma - physiopathology
Bronchial Hyperreactivity - diagnosis
Bronchial Hyperreactivity - physiopathology
Bronchial Provocation Tests - instrumentation
bronchoprovocation test
Child
dosimetric method
Female
Histamine
Humans
Male
Methacholine Chloride
Nebulizers and Vaporizers
Oscillometry
Spirometry
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Summary:To explore the use of oscillometry as a measure of airway responsiveness, 69 asthmatic children underwent histamine and methacholine bronchoprovocation using dosimeter-MedicAid (Jaeger Co.; Germany) and DeVilbiss nebulizers (DeVilbiss, Bornemouth; England). The mean increase in R5 resistance in challenge testing measured after methacholine with the dosimeter-MedicAid nebulizer was 77.14% compared with 65.05% using histamine. Using the dosimeter-DeVilbiss nebulizer, the mean increases in R5 resistance following methacholine and histamine testing were 57.50% and 59.36%, respectively. The resistance R5 over R20 significantly correlated with forced expiratory volume in 1 second (FEV1). The MedicAid produced a more aggressive challenge than the DeVilbliss nebulizer. Oscillometry can be used to monitor the level of airway hyperresponsiveness following bronchoprovocation tests.
ISSN:0277-0903
1532-4303
DOI:10.1080/02770900701246915