A similar 24-h blood pressure control is obtained by zofenopril and candesartan in primary hypertensive patients

Objective. To compare the antihypertensive effect of treatment with zofenopril vs candesartan by office and ambulatory blood pressure (BP). Design and methods. Following a 2-week wash-out from previous treatment, 236 grade I-II primary hypertensive patients were randomized double-blind to 12 weeks t...

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Bibliographic Details
Published in:Blood pressure 2006-01, Vol.15 (S1), p.18-26
Main Authors: Leonetti, G., Rappelli, A., Omboni, S., on Behalf of the Study Group
Format: Article
Language:English
Subjects:
Ambulatory blood pressure monitoring
candesartan
primary hypertension
smoothness index
trough-to-peak ratio
zofenopril
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Summary:Objective. To compare the antihypertensive effect of treatment with zofenopril vs candesartan by office and ambulatory blood pressure (BP). Design and methods. Following a 2-week wash-out from previous treatment, 236 grade I-II primary hypertensive patients were randomized double-blind to 12 weeks treatment with zofenopril 30 mg or candesartan 8 mg od. After 4 weeks, treatment was doubled in responder non-normalized (office systolic BP 140 mmHg and office diastolic BP reduction 10 mmHg) or non-responder patients (office systolic BP 140 mmHg and office diastolic BP reduction
ISSN:0803-7051
1651-1999
DOI:10.1080/08038020510046689