MAINTENANCE IMMUNOTHERAPY BY REPETITIVE LOW-DOSE DONOR LYMPHOCYTES INFUSIONS IN A CHILD WITH RELAPSE STATE AML AFTER ALLOGENEIC STEM CELL TRANSPLANTATION

The treatment of a child with a relapsed state acute leukemia after allogeneic stem cell transplantation (allo-SCT) is a challenge. The authors report about a child with an acute myelogenous leukemia (AML), which relapsed after allo-SCT despite immunological intervention. It was further treated with...

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Bibliographic Details
Published in:Pediatric hematology and oncology 2007-01, Vol.24 (2), p.137-140
Main Authors: Hartwig, M., Weigel, S., Bernig, T., Bader, P., Dölken, R., Beck, J.
Format: Article
Language:English
Subjects:
acute myeloid leukemia
allogeneic stem cell transplantation
Blood Donors
donor lymphocyte infusion
Dose-Response Relationship, Immunologic
Female
Graft vs Host Disease - etiology
Graft vs Host Disease - therapy
Humans
Immunotherapy
Infant
Leukemia, Myeloid, Acute - complications
Leukemia, Myeloid, Acute - therapy
Lymphocyte Transfusion
mixed chimerism
Neoplasm Recurrence, Local - therapy
Stem Cell Transplantation
Transplantation, Homologous
Treatment Outcome
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Summary:The treatment of a child with a relapsed state acute leukemia after allogeneic stem cell transplantation (allo-SCT) is a challenge. The authors report about a child with an acute myelogenous leukemia (AML), which relapsed after allo-SCT despite immunological intervention. It was further treated with a second line chemotherapy followed by an infusion of stem cells and donor lymphocytes. Because of an immense risk for a further relapse, an immunological maintenance therapy was also performed, consisting of repetitive infusions of low doses of donor lymphocytes combined with low-dose chemotherapy. Presently, the child is in continuous complete remission and has a good quality of life.
ISSN:0888-0018
1521-0669
DOI:10.1080/08880010601125443