Integron-associated antimicrobial resistance in isolates of members of Enterobacteriaceae causing community-acquired urinary infections

The present study investigated 73 isolates of Enterobacteriaceae obtained from urine samples of outpatients for the presence of integrons and analysed the association between integrons and antimicrobial susceptibility. Resistance to one or two antibiotics belonging to different classes was found in...

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Bibliographic Details
Published in:Microbial ecology in health and disease 2007, Vol.19 (3), p.201-206
Main Authors: Dakic, Ivana, Lilakos, Dinos, Svabic-Vlahovic, Milena, Christofilopoulou, Sofia, Poggas, Nikos, Charvalos, Ekatherina
Format: Article
Language:English
Subjects:
antimicrobial resistance
Enterobacteriaceae
Integrons
urinary tract infection
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Summary:The present study investigated 73 isolates of Enterobacteriaceae obtained from urine samples of outpatients for the presence of integrons and analysed the association between integrons and antimicrobial susceptibility. Resistance to one or two antibiotics belonging to different classes was found in 28 (38.4%) of the isolates, resistance to three or more antimicrobial agents with different mechanism of action, i.e. multidrug resistance in 37 (50.7%), while 8 (10.9%) were fully susceptible. The presence of integrons was shown in 13 (17.8%) of the strains tested: 9 (12.3%) carried a class 1 integron, 2 (2.7%) carried a class 2 integron, and 2 (2.7%) had both class 1 and class 2 integrons. Class 1 integron was clearly predominant, since 11 (84.6%) of 13 integron-positive isolates carried this class. No class 3 integron-positive isolates were detected. The association between the presence of an integron and multidrug resistance was highly significant (p
ISSN:0891-060X
1651-2235
1651-2235
DOI:10.1080/08910600701442773