Immunomodulatory Effects of Lingzhi and San-Miao-San Supplementation on Patients with Rheumatoid Arthritis

Rheumatoid arthritis (RA) is an autoimmune joint disease. We evaluated a standard preparation of Lingzhi (Ganoderma lucidum) and San-Miao-San (Rhizoma atractylodis, Cortex phellodendri, Radix achyranthes bidentatae) capsules (TCM group) for its supplementary treatment efficacy for RA. There was no s...

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Bibliographic Details
Published in:Immunopharmacology and immunotoxicology 2006, Vol.28 (2), p.197-200
Main Authors: Xi Bao, Yi, Kwok Wong, Chun, Kwok Ming Li, Edmund, Shan Tam, Lai, Chung Leung, Ping, Bing Yin, Yi, Wai Kei Lam, Christopher
Format: Article
Language:English
Subjects:
Achyranthes
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - drug therapy
CD4-CD8 Ratio
Cytokines - blood
Drugs, Chinese Herbal - administration & dosage
Female
Ganoderma lucidum
History, Ancient
Humans
Immunologic Factors - administration & dosage
Lymphocytes - metabolism
Male
Reishi
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Summary:Rheumatoid arthritis (RA) is an autoimmune joint disease. We evaluated a standard preparation of Lingzhi (Ganoderma lucidum) and San-Miao-San (Rhizoma atractylodis, Cortex phellodendri, Radix achyranthes bidentatae) capsules (TCM group) for its supplementary treatment efficacy for RA. There was no significant difference in the absolute count, percentage, and ratios of CD4+/CD8+/natural killer/B lymphocytes between the TCM and placebo groups after taking the capsules (all p > 0.05). There was no significant change in concentrations of plasma cytokines of interferon- -induced protein-10 (IP-10), monocyte chemoattractant protein-1, monokine induced by IFN- , regulated upon activation normal T-cell expressed and secreted, interleukin (IL)-8, and IL-18 after taking the capsules for 8 and 24 weeks (all p > 0.05). The percentage change in ex vivo-induced level of inflammatory cytokine IL-18 was significantly lower in the TCM group than in the placebo group after taking the capsules for 24 weeks (p < 0.05). Therefore, Lingzhi and San-Miao-San capsules might exert a beneficial immunomodulatory effect in patients with rheumatoid arthritis.
ISSN:0892-3973
1532-2513
DOI:10.1080/08923970600815097