Risperidone long-acting injection, a promising treatment for patients with bipolar disorder

Objective: Drug therapy for bipolar disorder is not always effective and full recovery between episodes can be elusive, resulting in great morbidity. Treatment approaches for the acute and long-term management of this disease are constantly being revised as new drugs become available. We wished to e...

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Bibliographic Details
Published in:Journal of mental health (Abingdon, England) England), 2005-10, Vol.14 (5), p.523-529
Main Authors: Dratcu, Luiz, Bamelis, Dominiek, Libretto, Susan E.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Antipsychotic drugs
antipsychotics
Biological and medical sciences
Bipolar affective disorder
Bipolar disorder
Bipolar disorders
Drug therapy
Effectiveness
intramuscular injection
long-acting
Medical sciences
Mental health
Mood disorders
Neuropharmacology
Pharmaceuticals
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychopharmacology
Risperidone
Treatment
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Summary:Objective: Drug therapy for bipolar disorder is not always effective and full recovery between episodes can be elusive, resulting in great morbidity. Treatment approaches for the acute and long-term management of this disease are constantly being revised as new drugs become available. We wished to examine a new treatment option - the long acting formulation of the atypical antipsychotic, risperidone. Case history: This paper describes a man with severe bipolar disorder who has been unsuccessfully treated for many years with mood stabilizers, antidepressants and antipsychotics, and who has shown significant and prolonged amelioration of his symptoms following treatment using risperidone long-acting injection 25 mg given intramuscularly every two weeks. Discussion: The factors underlying the potential effectiveness of this medication in patients with bipolar disorder are discussed. Conclusion: This case illustrates the suitability of long-acting risperidone in patients with bipolar disorder requiring long-term pharmacotherapy and raises the prospect of using it in the prophylaxis of patients who are at risk of relapse. Declaration of interest: Dr Susan Libretto formerly worked as a Medical Writer & Publications Manager for Janssen-Cilag Ltd. There is no conflict of interest. The patient gave permission for the writing of this article.
ISSN:0963-8237
1360-0567
DOI:10.1080/09638230500271436