Expression and cDNA Sequence of Matrix Metalloproteinase-2 (MMP-2) in a Mammalian Model of Human Disease Processes: Tupaia belangeri

Matrix metalloproteinase-2 (MMP-2) is one of a family of proteolytic enzymes that are involved in the remodelling of tissue during normal growth processes and is capable of degrading structural components of the extracellular matrix. Increases in MMP-2 expression and activity have been reported in d...

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Bibliographic Details
Published in:DNA sequence 2004, Vol.15 (5-6), p.332-337
Main Authors: Kenning, Megan S., Gentle, Alex, McBrien, Neville A.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Connective tissue
Disease Models, Animal
DNA Primers
Extracellular matrix
Gene Expression
Matrix Metalloproteinase 2 - genetics
Molecular Sequence Data
mRNA
Primates
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
RNA, Messenger - metabolism
Sequence Alignment
Sequence Analysis, DNA
Species Specificity
Tree shrew
Tupaia - genetics
Tupaia belangeri
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Summary:Matrix metalloproteinase-2 (MMP-2) is one of a family of proteolytic enzymes that are involved in the remodelling of tissue during normal growth processes and is capable of degrading structural components of the extracellular matrix. Increases in MMP-2 expression and activity have been reported in diseases that involve degradation of the extracellular matrix. Reported here for the first time are the relative levels of expression of MMP-2 in tissues of the tree shrew along with 2587 bases of the mRNA sequence. Translation of this sequence predicts a protein 660 amino acids in length, containing all of the features expected of mammalian MMP-2. The tree shrew is a species close to the primate line and is an emerging animal model for a variety of human diseases, including hepatitis and myopia that feature MMP-2 mediated remodelling of the extracellular matrix.
ISSN:1042-5179
1029-2365
DOI:10.1080/10425170400012925