Four-Year Survival After Trans-jugular Intrahepatic Porto-systemic Shunt for Veno-occlusive Disease Following Autologous Bone Marrow Transplantation

Severe hepatic veno-occlusive disease is still a potentially lethal complication after bone marrow transplantation. We here report the case of a patient who developed liver veno-occlusive disease with severe hemodynamic dysfunction and was successfully treated by means of a trans-jugular intrahepati...

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Bibliographic Details
Published in:Leukemia & lymphoma 2004-07, Vol.45 (7), p.1485-1487
Main Authors: Annaloro, Claudio, Robbiolo, Livia, Pozzoli, Ermanno, Ibatici, Adalberto, Nicolini, Antonio, Salerno, Francesco, Deliliers, Giorgio Lambertenghi
Format: Article
Language:English
Subjects:
Adult
Bone marrow transplantation
Carmustine - adverse effects
Combined Modality Therapy
Cyclophosphamide - adverse effects
Etoposide - adverse effects
Hemodynamics
Hepatic Veno-Occlusive Disease - chemically induced
Hepatic Veno-Occlusive Disease - physiopathology
Hepatic Veno-Occlusive Disease - surgery
Humans
Jugular Veins
Lymphoma, Large-Cell, Anaplastic - therapy
Male
Peripheral Blood Stem Cell Transplantation
Portasystemic Shunt, Surgical
Remission Induction
Thrombophilia - etiology
Trans-jugular intrahepatic portosystemic shunt
Transplantation Conditioning - adverse effects
Transplantation, Autologous
Veno-occlusive liver disease
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Summary:Severe hepatic veno-occlusive disease is still a potentially lethal complication after bone marrow transplantation. We here report the case of a patient who developed liver veno-occlusive disease with severe hemodynamic dysfunction and was successfully treated by means of a trans-jugular intrahepatic portosystemic shunt. After three years, he is still disease-free with a functioning shunt and a normal laboratory liver profile. A trans-jugular intrahepatic portosystemic shunt is a treatment option that has been used in very few patients affected by hepatic veno-occlusive disease; its indications and timing remain to be established.
ISSN:1042-8194
1029-2403
DOI:10.1080/10428190410001663626