Caffeic acid derivatives in artichoke extract are metabolised to phenolic acids in vivo

The purpose of this study was to investigate the absorption and metabolism of hydroxycinnamates from artichoke extract by determining the urinary excretion of the conjugates. Ten healthy, non smoking volunteers (5 female, 5 male) were given three capsules containing artichoke extract every 4 h (0, 4...

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Bibliographic Details
Published in:Free radical research 2001-01, Vol.35 (2), p.195-202
Main Authors: Rechner, Andreas R., Pannala, Ananth Sekher, Rice-Evans, Catherine A.
Format: Article
Language:English
Subjects:
absorption
Adult
Artichoke
Biological Availability
Caffeic Acids - administration & dosage
Caffeic Acids - chemistry
Caffeic Acids - metabolism
Caffeic Acids - pharmacokinetics
Chromatography, High Pressure Liquid
Coumaric Acids - metabolism
Coumaric Acids - pharmacokinetics
Coumaric Acids - urine
Creatinine - metabolism
Creatinine - urine
Diet
Female
ferulic acid
Gastric Juice - metabolism
Humans
Hydroxybenzoates - metabolism
Hydroxybenzoates - pharmacokinetics
Hydroxybenzoates - urine
Male
metabolism
methylation
phenolic acids
Vanillic Acid - metabolism
Vanillic Acid - urine
Vegetables - chemistry
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Summary:The purpose of this study was to investigate the absorption and metabolism of hydroxycinnamates from artichoke extract by determining the urinary excretion of the conjugates. Ten healthy, non smoking volunteers (5 female, 5 male) were given three capsules containing artichoke extract every 4 h (0, 4, 8h) following two days of a low-polyphenol diet. One capsule contained 320 mg of artichoke extract equivalent to 34.3 ± 0.6 mg/g hydroxycinnamates (caffeic acid derivatives) and 5.6 ± 0.1 mg/g flavonoids. Polyphenols and phenolic acids present in the artichoke extract were not detected in the urine either as conjugates or aglycones. However, ferulic, isoferulic, dihydroferulic and vanillic acid were identified as major metabolites after β-glucuronidase treatment of urine. The amount excreted as well as the ratio to that of creatinine, a biomarker for the general excretion rate, increased significantly on the study day compared to the presupplementation day. Thus, the caffeic acid esters found in the artichoke extract capsule are absorbed, metabolised and excreted as methylated phenolic acids such as ferulic, isoferulic, dihydroferulic and vanillic acid.
ISSN:1071-5762
1029-2470
DOI:10.1080/10715760100300741