Oxidative Stress and Myocardial Damage during Elective Percutaneous Coronary Interventions and Coronary AngiographyA Comparison of Blood-borne Isoprostane and Troponin Release

The role of oxidative stress in clinical cardiology is still controversial. The aims of the present study were to examine if minor ischaemic episodes as may occur during elective percutaneous coronary intervention (PCI) induce oxidative stress and, eventually, if oxygen stress correlates with myocar...

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Bibliographic Details
Published in:Free radical research 2004-05, Vol.38 (5), p.517-525
Main Authors: Berg, Kirsti, Wiseth, Rune, Bjerve, Kristian, Brurok, Heidi, Gunnes, Sigurd, Skarra, Sissel, Jynge, Per, Basu, Samar
Format: Article
Language:English
Subjects:
Coronary angiography
Ischaemia-reperfusion
Isoprostanes
Percutaneous coronary intervention
Reactive oxygen species
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Summary:The role of oxidative stress in clinical cardiology is still controversial. The aims of the present study were to examine if minor ischaemic episodes as may occur during elective percutaneous coronary intervention (PCI) induce oxidative stress and, eventually, if oxygen stress correlates with myocardial injury. Thirty eight and nine patients underwent PCI and diagnostic coronary angiography, respectively. Peripheral blood was sampled at different time points for plasma analyses of: 8-iso-PGF2 (free radical-mediated oxidative stress); 15-keto-dihydro-PGF2 (cyclooxygenase-mediated inflammation); troponin-T (myocardial injury); hsCRP, vitamin A and vitamin E; and, total antioxidants status (TAS). In both groups 8-iso-PGF2 increased transiently by approximately 80% (p
ISSN:1071-5762
1029-2470
DOI:10.1080/10715760410001688339