A Cell-Based Drug Delivery System for Lung Targeting: II. Therapeutic Activities on B16-F10 Melanoma in Mouse Lungs

The in vitro and in vivo anticancer activities of doxorubicin-loaded B16-F10 murine melanoma cells (DLTC) were evaluated. DLTC showed similar growth-inhibitory effects against live B16-F10 cells with doxorubicin solution in cell culture system, with the IC50

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Bibliographic Details
Published in:Drug delivery 2001-04, Vol.8 (2), p.71-76
Main Author: Jun Shao, Jean DeHaven, Donald Lamm, David N. Weissman, Carl J. Malanga, Yongyut Rojanasakul, Joseph K. H. Ma
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic - administration & dosage
Antibiotics, Antineoplastic - pharmacokinetics
Antibiotics, Antineoplastic - therapeutic use
Cell Adhesion
Doxorubicin - administration & dosage
Doxorubicin - pharmacokinetics
Doxorubicin - therapeutic use
Drug Delivery Systems
Drug Stability
Female
Flow Cytometry
Lung Neoplasms - drug therapy
Melanoma Doxorubicin Lung Cancer Treatment Targeting Drug Delivery
Melanoma, Experimental - drug therapy
Mice
Mice, Inbred C57BL
Particle Size
Tissue Distribution
Trypsin - chemistry
Tumor Cells, Cultured
Online Access:Get full text
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Description
Summary:The in vitro and in vivo anticancer activities of doxorubicin-loaded B16-F10 murine melanoma cells (DLTC) were evaluated. DLTC showed similar growth-inhibitory effects against live B16-F10 cells with doxorubicin solution in cell culture system, with the IC50
ISSN:0049-8254
1071-7544
1366-5928
1521-0464
DOI:10.1080/107175401750177007