Breath biomarkers and non-alcoholic fatty liver disease: Preliminary observations

Abstract Breath biomarkers have the potential to offer information that is similar to conventional clinical tests or they are entirely unique. Preliminary data support the use of breath biomarkers in the study of liver disease, in particular non-alcoholic fatty liver disease (NAFLD). It was evaluate...

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Bibliographic Details
Published in:Biomarkers 2006-03, Vol.11 (2), p.174-183
Main Authors: Solga, S. F., Alkhuraishe, A., Cope, K., Tabesh, A., Clark, J. M., Torbenson, M., Schwartz, P., Magnuson, T., Diehl, A. M., Risby, T. H.
Format: Article
Language:English
Subjects:
Acetone - analysis
Adult
Biological and medical sciences
biomarker
Biomarkers - analysis
Breath
Breath Tests
Carbon Dioxide - analysis
Ethanol - analysis
Fatty Liver - metabolism
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
liver disease
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
non-alcoholic fatty liver
Other diseases. Semiology
Sulfur - analysis
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Summary:Abstract Breath biomarkers have the potential to offer information that is similar to conventional clinical tests or they are entirely unique. Preliminary data support the use of breath biomarkers in the study of liver disease, in particular non-alcoholic fatty liver disease (NAFLD). It was evaluated whether breath ethanol, ethane, sulfur compounds and acetone would be associated with hepatic histopathology amongst morbidly obese patients presenting for bariatric surgery. Breath samples were collected during a preoperative visit and compared with liver biopsies obtained during the surgery. A Student's two-tailed t-test was used to compare differences between the two groups. Linear regression was used to analyse associations between the concentrations of breath molecules and independent predictor variables. It was found that breath ethanol, ethane and acetone can be useful biomarkers in patients with NAFLD. In particular, breath ethanol can be associated with hepatic steatosis, and breath acetone can be associated with non-alcoholic steatohepatitis.
ISSN:1354-750X
1366-5804
DOI:10.1080/13547500500421070