Markedly elevated serum alkaline phosphatase level in an uncomplicated pregnancy

In normal pregnancy, although maternal serum alkaline phosphatase increases and reaches the two-fold of non-pregnant serum level, above this level, hepatic, renal, osteal diseases and malignancies should be kept in mind. We report a case of 28-year-old pregnant woman with increased maternal serum le...

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Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2009-01, Vol.22 (8), p.705-707
Main Authors: Celik, Handan, Tosun, Midraci, Çetinkaya, Mehmet Bilge, Bektab, Ahmet, Malatyalýodlu, Erdal
Format: Article
Language:English
Subjects:
Adult
Alkaline phosphatase
Alkaline Phosphatase - blood
Diagnosis, Differential
Female
Humans
Infant, Newborn
Isoenzymes - blood
Placenta - enzymology
placental isozyme
Pregnancy
Pregnancy Outcome
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Summary:In normal pregnancy, although maternal serum alkaline phosphatase increases and reaches the two-fold of non-pregnant serum level, above this level, hepatic, renal, osteal diseases and malignancies should be kept in mind. We report a case of 28-year-old pregnant woman with increased maternal serum level of alkaline phosphatase activity (17-fold) due to an increased level of placental isozyme. She delivered vaginally a healthy female baby. After delivery, maternal serum alkaline phosphatase activity returned to normal reference range. The aim of this case report is to show this exaggerated isozyme activity of alkaline phosphatase in pregnancy, and to differentiate it from other causes of elevated level of alkaline phosphatase.
ISSN:1476-7058
1476-4954
DOI:10.1080/14767050802702323