Current Concepts in Lymphocyte Homing and Recirculation

Referee: Dr. E.J. Kundel, 154-B VAML, 3801 Miranda Ave, Palo Alto, CA 94304 ALTA The immune system consists of a complex collection of leukocytes and dendritic cells that surveys most tissues in the body for the appearance of foreign antigens. For an efficient immune response, the interaction and co...

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Bibliographic Details
Published in:Critical reviews in clinical laboratory sciences 2001-01, Vol.38 (1), p.1-31
Main Authors: Wiedle, Guido, Dunon, Dominique, Imhof, Beat A.
Format: Article
Language:English
Subjects:
Animals
Antigens, Differentiation, Myelomonocytic - immunology
cell adhesion
Cell Adhesion Molecules - physiology
cell migration
Cell Movement - immunology
chemokines
Cytokines - immunology
Endothelium, Vascular - immunology
Humans
immune defense
lymphocyte homing
Lymphocytes - immunology
Lymphoid Tissue - immunology
Platelet Endothelial Cell Adhesion Molecule-1 - immunology
Receptors, Lymphocyte Homing - physiology
recirculation
transendothelial migration
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Summary:Referee: Dr. E.J. Kundel, 154-B VAML, 3801 Miranda Ave, Palo Alto, CA 94304 ALTA The immune system consists of a complex collection of leukocytes and dendritic cells that surveys most tissues in the body for the appearance of foreign antigens. For an efficient immune response, the interaction and co-localization of antigen-presenting cells, co-stimulatory helper cells and effector cells are crucial parameters. Therefore, the migration routes of antigen-presenting cells and potential antigen-specific lymphocytes merge in secondary lymphoid organs in order to increase the likelihood and speed of a lymphocyte finding its cognate antigen. Additionally, antigen-primed effector cells are directed to the tissue where they are most likely to encounter their cognate antigen. This highly organized and efficient antigen encounter is based on a continuous recirculation of antigen-specific lymphocytes between blood, peripheral tissue, and secondary lymphoid organs. Moreover, the efficacy of the immune system is further increased by the ability of different lymphocyte subsets to recirculate only through distinct tissues. The scope of this review is to outline the concept and mechanisms of lymphocyte homing and recirculation and to discuss the significance for the immune defense. Current models in leukocyte homing and recirculation and the underlying molecular functions of implicated cell adhesion molecules, chemokines, and chemokine receptors are discussed.
ISSN:1040-8363
1549-781X
DOI:10.1080/20014091084164