ASSOCIATION OF THE G PROTEIN β3 SUBUNIT T ALLELE WITH INSULIN RESISTANCE IN ESSENTIAL HYPERTENSION

A polymorphism (C825T) in the gene encoding the G protein β3 subunit (GNB3) has recently been associated with hypertension and obesity in several populations. The aim of the study was to analyse the relationship between this polymorphism and insulin sensitivity, an hypothesised unifying factor for h...

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Published in:Clinical and experimental hypertension (1993) 2002, Vol.24 (5), p.345-353
Main Authors: Poch, Esteban, Giner, Vicente, González-Núñez, Daniel, Coll, Elisabeth, Oriola, Josep, de la Sierra, Alejandro
Format: Article
Language:English
Subjects:
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
G proteins
Genetics
Hypertension
Insulin resistance
Medical sciences
Obesity
Polymorphism
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Summary:A polymorphism (C825T) in the gene encoding the G protein β3 subunit (GNB3) has recently been associated with hypertension and obesity in several populations. The aim of the study was to analyse the relationship between this polymorphism and insulin sensitivity, an hypothesised unifying factor for hypertension and obesity. One hundred thirty unrelated patients with essential hypertension, 70 female and 60 male, aged 58±1 years with systolic blood pressure of 173±2 mm Hg and diastolic blood pressure of 105±1 mm Hg, were genotyped for the GNB3 polymorphism by PCR and restriction digestion with BseDI, and classified in two groups according to the genotypes CC and CT+TT. Body mass index (BMI) was significantly higher in patients with the T allele as compared with patients without the T allele (29.3±0.4 vs. 26.7±0.6 kg m2, p
ISSN:1064-1963
1525-6006
DOI:10.1081/CEH-120004796