ASSOCIATION OF THE G PROTEIN β3 SUBUNIT T ALLELE WITH INSULIN RESISTANCE IN ESSENTIAL HYPERTENSION

A polymorphism (C825T) in the gene encoding the G protein β3 subunit (GNB3) has recently been associated with hypertension and obesity in several populations. The aim of the study was to analyse the relationship between this polymorphism and insulin sensitivity, an hypothesised unifying factor for h...

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Published in:Clinical and experimental hypertension (1993) 2002, Vol.24 (5), p.345-353
Main Authors: Poch, Esteban, Giner, Vicente, González-Núñez, Daniel, Coll, Elisabeth, Oriola, Josep, de la Sierra, Alejandro
Format: Article
Language:English
Subjects:
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
G proteins
Genetics
Hypertension
Insulin resistance
Medical sciences
Obesity
Polymorphism
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container_issue 5
container_start_page 345
container_title Clinical and experimental hypertension (1993)
container_volume 24
creator Poch, Esteban
Giner, Vicente
González-Núñez, Daniel
Coll, Elisabeth
Oriola, Josep
de la Sierra, Alejandro
description A polymorphism (C825T) in the gene encoding the G protein β3 subunit (GNB3) has recently been associated with hypertension and obesity in several populations. The aim of the study was to analyse the relationship between this polymorphism and insulin sensitivity, an hypothesised unifying factor for hypertension and obesity. One hundred thirty unrelated patients with essential hypertension, 70 female and 60 male, aged 58±1 years with systolic blood pressure of 173±2 mm Hg and diastolic blood pressure of 105±1 mm Hg, were genotyped for the GNB3 polymorphism by PCR and restriction digestion with BseDI, and classified in two groups according to the genotypes CC and CT+TT. Body mass index (BMI) was significantly higher in patients with the T allele as compared with patients without the T allele (29.3±0.4 vs. 26.7±0.6 kg m2, p
doi_str_mv 10.1081/CEH-120004796
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The aim of the study was to analyse the relationship between this polymorphism and insulin sensitivity, an hypothesised unifying factor for hypertension and obesity. One hundred thirty unrelated patients with essential hypertension, 70 female and 60 male, aged 58±1 years with systolic blood pressure of 173±2 mm Hg and diastolic blood pressure of 105±1 mm Hg, were genotyped for the GNB3 polymorphism by PCR and restriction digestion with BseDI, and classified in two groups according to the genotypes CC and CT+TT. Body mass index (BMI) was significantly higher in patients with the T allele as compared with patients without the T allele (29.3±0.4 vs. 26.7±0.6 kg m2, p&lt;0.001). On the contrary, there were no differences in the level of systolic or diastolic blood pressure among the genotypes. Insulin sensitivity was measured in a subgroup of 35 patients by means of an euglycemic hyperinsulinemic clamp test. In this subgroup, patients with the T allele displayed lower insulin sensitivity index (1.6±0.3 vs. 2.7±0.3 mg kg min, p=0.022), higher fasting serum insulin (121±16 vs. 77±11 pmol L, p=0.032), higher serum glucose 120 min after 75 g load (9.8±1.2 vs. 7.0±0.5 mmol L, p=0.038), and higher glycosilated haemoglobin (5.7±0.4 vs. 4.7±0.2%; p=0.042) as compared with patients without the T allele. A regression analysis showed that the association between the T allele and insulin sensitivity was independent of BMI (β coefficient −0.386, p=0.022). These results suggest a relationship between the 825T allele of GNB3 and insulin resistance in the essential hypertensive patients studied, which seems to be independent of BMI.</description><identifier>ISSN: 1064-1963</identifier><identifier>EISSN: 1525-6006</identifier><identifier>DOI: 10.1081/CEH-120004796</identifier><identifier>CODEN: CEHYER</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. 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The aim of the study was to analyse the relationship between this polymorphism and insulin sensitivity, an hypothesised unifying factor for hypertension and obesity. One hundred thirty unrelated patients with essential hypertension, 70 female and 60 male, aged 58±1 years with systolic blood pressure of 173±2 mm Hg and diastolic blood pressure of 105±1 mm Hg, were genotyped for the GNB3 polymorphism by PCR and restriction digestion with BseDI, and classified in two groups according to the genotypes CC and CT+TT. Body mass index (BMI) was significantly higher in patients with the T allele as compared with patients without the T allele (29.3±0.4 vs. 26.7±0.6 kg m2, p&lt;0.001). On the contrary, there were no differences in the level of systolic or diastolic blood pressure among the genotypes. Insulin sensitivity was measured in a subgroup of 35 patients by means of an euglycemic hyperinsulinemic clamp test. In this subgroup, patients with the T allele displayed lower insulin sensitivity index (1.6±0.3 vs. 2.7±0.3 mg kg min, p=0.022), higher fasting serum insulin (121±16 vs. 77±11 pmol L, p=0.032), higher serum glucose 120 min after 75 g load (9.8±1.2 vs. 7.0±0.5 mmol L, p=0.038), and higher glycosilated haemoglobin (5.7±0.4 vs. 4.7±0.2%; p=0.042) as compared with patients without the T allele. A regression analysis showed that the association between the T allele and insulin sensitivity was independent of BMI (β coefficient −0.386, p=0.022). These results suggest a relationship between the 825T allele of GNB3 and insulin resistance in the essential hypertensive patients studied, which seems to be independent of BMI.</description><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>G proteins</subject><subject>Genetics</subject><subject>Hypertension</subject><subject>Insulin resistance</subject><subject>Medical sciences</subject><subject>Obesity</subject><subject>Polymorphism</subject><issn>1064-1963</issn><issn>1525-6006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNptkNFKwzAUhoMoOKeX3ufGy2qyNElzWUtcA6UdS4p4VbI2ZR3dOtqJ7LV8EJ_JylQQvDqHw_f9cH4AbjG6xyjAD5GMPTxDCPlcsDMwwXRGPYYQOx93xHwPC0YuwdUwbBDCPqPBBJSh1lmkQqOyFGZP0MQSzuFimRmpUvjxTqDOH_NUGWhgmCQykfBZmRiqVOfJSCylVtqEaSTHE5Ray9SoMIHxy0IujUz1mHsNLmrbDu7me05B_iRNFHtJNldRmHgNFvTgMVrWbCWqVVU5f-WoExXhFeeUzDj1RTkrqQt4wBAJMBe0Rs5xjqvSoZrXvqBkCu5OuXs7lLate7srm6HY983W9scCE-77lIuRC05cs6u7fmvfur6tioM9tl3_IxGMiq9Si7HU4rfUUeV_1LWz7WFd2t4Vm-61343vFf-bn3uIdHU</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>Poch, Esteban</creator><creator>Giner, Vicente</creator><creator>González-Núñez, Daniel</creator><creator>Coll, Elisabeth</creator><creator>Oriola, Josep</creator><creator>de la Sierra, Alejandro</creator><general>Informa UK Ltd</general><general>Taylor &amp; Francis</general><scope>IQODW</scope></search><sort><creationdate>2002</creationdate><title>ASSOCIATION OF THE G PROTEIN β3 SUBUNIT T ALLELE WITH INSULIN RESISTANCE IN ESSENTIAL HYPERTENSION</title><author>Poch, Esteban ; Giner, Vicente ; González-Núñez, Daniel ; Coll, Elisabeth ; Oriola, Josep ; de la Sierra, Alejandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i195t-65cf6b9dbdde4be5e9d37d775327549c2c5e87860381795f0ee771dce0f7f4953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>G proteins</topic><topic>Genetics</topic><topic>Hypertension</topic><topic>Insulin resistance</topic><topic>Medical sciences</topic><topic>Obesity</topic><topic>Polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Poch, Esteban</creatorcontrib><creatorcontrib>Giner, Vicente</creatorcontrib><creatorcontrib>González-Núñez, Daniel</creatorcontrib><creatorcontrib>Coll, Elisabeth</creatorcontrib><creatorcontrib>Oriola, Josep</creatorcontrib><creatorcontrib>de la Sierra, Alejandro</creatorcontrib><collection>Pascal-Francis</collection><jtitle>Clinical and experimental hypertension (1993)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Poch, Esteban</au><au>Giner, Vicente</au><au>González-Núñez, Daniel</au><au>Coll, Elisabeth</au><au>Oriola, Josep</au><au>de la Sierra, Alejandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ASSOCIATION OF THE G PROTEIN β3 SUBUNIT T ALLELE WITH INSULIN RESISTANCE IN ESSENTIAL HYPERTENSION</atitle><jtitle>Clinical and experimental hypertension (1993)</jtitle><date>2002</date><risdate>2002</risdate><volume>24</volume><issue>5</issue><spage>345</spage><epage>353</epage><pages>345-353</pages><issn>1064-1963</issn><eissn>1525-6006</eissn><coden>CEHYER</coden><abstract>A polymorphism (C825T) in the gene encoding the G protein β3 subunit (GNB3) has recently been associated with hypertension and obesity in several populations. The aim of the study was to analyse the relationship between this polymorphism and insulin sensitivity, an hypothesised unifying factor for hypertension and obesity. One hundred thirty unrelated patients with essential hypertension, 70 female and 60 male, aged 58±1 years with systolic blood pressure of 173±2 mm Hg and diastolic blood pressure of 105±1 mm Hg, were genotyped for the GNB3 polymorphism by PCR and restriction digestion with BseDI, and classified in two groups according to the genotypes CC and CT+TT. Body mass index (BMI) was significantly higher in patients with the T allele as compared with patients without the T allele (29.3±0.4 vs. 26.7±0.6 kg m2, p&lt;0.001). On the contrary, there were no differences in the level of systolic or diastolic blood pressure among the genotypes. Insulin sensitivity was measured in a subgroup of 35 patients by means of an euglycemic hyperinsulinemic clamp test. In this subgroup, patients with the T allele displayed lower insulin sensitivity index (1.6±0.3 vs. 2.7±0.3 mg kg min, p=0.022), higher fasting serum insulin (121±16 vs. 77±11 pmol L, p=0.032), higher serum glucose 120 min after 75 g load (9.8±1.2 vs. 7.0±0.5 mmol L, p=0.038), and higher glycosilated haemoglobin (5.7±0.4 vs. 4.7±0.2%; p=0.042) as compared with patients without the T allele. A regression analysis showed that the association between the T allele and insulin sensitivity was independent of BMI (β coefficient −0.386, p=0.022). These results suggest a relationship between the 825T allele of GNB3 and insulin resistance in the essential hypertensive patients studied, which seems to be independent of BMI.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><doi>10.1081/CEH-120004796</doi><tpages>9</tpages></addata></record>
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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
G proteins
Genetics
Hypertension
Insulin resistance
Medical sciences
Obesity
Polymorphism
title ASSOCIATION OF THE G PROTEIN β3 SUBUNIT T ALLELE WITH INSULIN RESISTANCE IN ESSENTIAL HYPERTENSION
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