P450 SUBFAMILY CYP2J AND THEIR ROLE IN THE BIOACTIVATION OF ARACHIDONIC ACID IN EXTRAHEPATIC TISSUES1

Historically, there has been intense interest in P450 metabolic oxidation, peroxidation, and reduction of xenobiotics. More recently, there has been a growing appreciation for the role of P450s in the oxidation of lipophilic endobiotics, such as bile acids, fat-soluble vitamins, and eicosanoids. Thi...

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Bibliographic Details
Published in:Drug metabolism reviews 1999, Vol.31 (1), p.205-234
Main Authors: SCARBOROUGH, PAULA E., MA, JIXIANG, QU, WEI, ZELDIN, DARRYL C.
Format: Article
Language:English
Online Access:Get full text
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Summary:Historically, there has been intense interest in P450 metabolic oxidation, peroxidation, and reduction of xenobiotics. More recently, there has been a growing appreciation for the role of P450s in the oxidation of lipophilic endobiotics, such as bile acids, fat-soluble vitamins, and eicosanoids. This review details the emerging CYP2J subfamily of P450s and their role as catalysts of arachidonic acid metabolism.
ISSN:0360-2532
1097-9883
DOI:10.1081/DMR-100101915