Functional MRI-Based Therapeutic rTMS Strategy for Aphasic Stroke Patients: A Case Series Pilot Study

ABSTRACT Four poststroke patients with motor-dominant aphasia received 10 treatment sessions of low-frequency repetitive transcranial magnetic stimulation (rTMS). Each treatment session consisted of 1,200 pulses of stimulation and the site of stimulation was an area homologous to the most activated...

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Bibliographic Details
Published in:International journal of neuroscience 2010-01, Vol.120 (1), p.60-66
Main Authors: Kakuda, Wataru, Abo, Masahiro, Kaito, Nobuyoshi, Watanabe, Motoi, Senoo, Atsushi
Format: Article
Language:English
Subjects:
Aged
aphasia
Aphasia - etiology
Aphasia - pathology
Aphasia - therapy
Brain - blood supply
Brain - physiopathology
Brain Mapping
functional MRI
Humans
Image Processing, Computer-Assisted - methods
Language
language function
Magnetic Resonance Imaging - methods
Male
Middle Aged
Neuropsychological Tests
Oxygen - blood
Pilot Projects
rehabilitation
repetitive transcranial magnetic stimulation
stroke
Stroke - complications
Transcranial Magnetic Stimulation - methods
Verbal Behavior - physiology
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Summary:ABSTRACT Four poststroke patients with motor-dominant aphasia received 10 treatment sessions of low-frequency repetitive transcranial magnetic stimulation (rTMS). Each treatment session consisted of 1,200 pulses of stimulation and the site of stimulation was an area homologous to the most activated site on functional MRI performed prior to rTMS. Consequently, rTMS was applied to the right frontal lobe in two patients and to the left frontal lobe in two patients. Treatment resulted in improvement of language function in all four patients. Our therapeutic rTMS strategy seems to be a clinically feasible neurorehabilitative approach for poststroke aphasic patients.
ISSN:0020-7454
1563-5279
1543-5245
DOI:10.3109/00207450903445628