Hashimoto's encephalopathy: four cases and review of literature

Hashimoto's encephalopathy is a rare clinically heterogenous condition consisting of encephalopathy, seizures and variable neurological and psychiatric manifestations, accompanied by high titres of serum antithyroid antibodies. We described the clinical and laboratory findings of four children...

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Bibliographic Details
Published in:International journal of neuroscience 2014-04, Vol.124 (4), p.302-306
Main Authors: Gul Mert, Gülen, Horoz, Ozden Ozgur, Herguner, M. Ozlem, Incecik, Faruk, Yildizdas, R. Dincer, Onenli Mungan, Neslihan, Yuksel, Bilgin, Altunbasak, Sakir
Format: Article
Language:English
Subjects:
Adolescent
Brain Diseases - drug therapy
Brain Diseases - therapy
Child
Encephalitis
Female
Glucocorticoids - therapeutic use
Hashimoto Disease - drug therapy
Hashimoto Disease - therapy
Hashimoto's encephalopathy
Humans
Male
Plasmapheresis
seizure
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Summary:Hashimoto's encephalopathy is a rare clinically heterogenous condition consisting of encephalopathy, seizures and variable neurological and psychiatric manifestations, accompanied by high titres of serum antithyroid antibodies. We described the clinical and laboratory findings of four children (aged 8-17 years) with Hashimoto's encephalopathy. The clinical features of three patients at presentation included refractory epilepsy, and confusion, and one patient presented with behavioral and cognitive changes. During their presentation, two of them were in euthyroid, and the others were in hypothyroid status. All patients manifested increased antithyroid antibodies. Two patients improved with steroid treatment. The others responded to plasmapheresis instead of corticosteroid treatment. Physicians' awareness of this complication is of great importance because most patients respond dramatically to the treatment.
ISSN:0020-7454
1563-5279
1543-5245
DOI:10.3109/00207454.2013.836706