Negative HCV-RNA 2 weeks after initiation of treatment predicts sustained virological response to pegylated interferon alfa-2a and ribavirin in patients with chronic hepatitis C

Abstract Objective. The aim of this study was to examine the early viral kinetics as predictor for sustained virological response (SVR) during hepatitis C treatment. Materials and methods. We included patients with biopsy-proven chronic hepatitis C and ALT above the upper limit of normal, who receiv...

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Published in:Scandinavian journal of gastroenterology 2012-09, Vol.47 (8-9), p.1115-1119
Main Authors: Christensen, Peer Brehm, Krarup, Henrik Bygum, Laursen, Alex Lund, Madsen, Poul Henning, Pedersen, Court, Schlichting, Poul, Orholm, Marianne, Ring-Larsen, Helmer, Bukh, Jens, Krogsgaard, Kim
Format: Article
Language:English
Subjects:
Adult
Alanine Transaminase - blood
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - therapeutic use
Biological and medical sciences
Drug Therapy, Combination
Female
Gastroenterology. Liver. Pancreas. Abdomen
Genotype
Hepacivirus - genetics
hepatitis C
Hepatitis C, Chronic - blood
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - genetics
Human viral diseases
Humans
Infectious diseases
Interferon-alpha - therapeutic use
Interferons
Interleukins - genetics
Liver Cirrhosis - virology
Male
Medical sciences
Middle Aged
pegylated interferon alfa-2a
Pharmacology. Drug treatments
Polyethylene Glycols - therapeutic use
Predictive Value of Tests
Recombinant Proteins - therapeutic use
Ribavirin - therapeutic use
ribavirin concentration
RNA, Viral - blood
Time Factors
treatment
Treatment Outcome
Viral diseases
Viral hepatitis
viral kinetics
Viral Load
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Summary:Abstract Objective. The aim of this study was to examine the early viral kinetics as predictor for sustained virological response (SVR) during hepatitis C treatment. Materials and methods. We included patients with biopsy-proven chronic hepatitis C and ALT above the upper limit of normal, who received a standard treatment of pegylated interferon alfa-2a and ribavirin. The HCV-RNA concentration (limit of detection 20 IU/mL) was determined at days 0, 1, 2, 3, 4, 7, 14, 21 and monthly thereafter. Results. Among 46 patients who completed the trial, 30 (65%) had SVR. Low baseline viral load, IL28B genotype CC and absence of cirrhosis were statistically associated with SVR. In multivariate analysis only absence of cirrhosis and HCV-RNA negativity at day 14 were independent predictors for SVR. Eight patients who became HCV-RNA negative on day 14 as well as 13 of 14 patients (93%) with HCV-RNA levels of
ISSN:0036-5521
1502-7708
DOI:10.3109/00365521.2012.694905