The use of HbA1c as an aid in the diagnosis of gestational diabetes mellitus

Abstract The ability of HbA1c was evaluated in the diagnosis of gestational diabetes mellitus (GDM) and for the implications of its use in clinical practice. A total of 339 pregnant women with an estimated gestational age of 24-28 weeks were evaluated for GDM using an oral glucose tolerance test (OG...

Full description

Saved in:
Bibliographic Details
Published in:Journal of obstetrics and gynaecology 2014-11, Vol.34 (8), p.690-692
Main Authors: Sevket, O., Sevket, A., Ozel, A., Dansuk, R., Kelekci, S.
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Diabetes, Gestational - blood
Diabetes, Gestational - diagnosis
Female
Gestational diabetes mellitus
Glycated Hemoglobin A - metabolism
HbA
Humans
OGTT
Pregnancy
Prospective Studies
Young Adult
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The ability of HbA1c was evaluated in the diagnosis of gestational diabetes mellitus (GDM) and for the implications of its use in clinical practice. A total of 339 pregnant women with an estimated gestational age of 24-28 weeks were evaluated for GDM using an oral glucose tolerance test (OGTT) based on International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria. A ROC curve was drawn to determine the sensitivity and specificity of HbA1c in detecting GDM. An HbA1c cut-off value of ≥ 5.2% had sensitivity of 64.15% and specificity of 67.48% in diagnosing GDM, and a positive predictive value of 26.77%. Using two cut-offs in the 'rule-in and rule-out' algorithm, 94.4% of the GDM cases would have been detected but 33% (43 of the 130) women would had been misclassified. HbA1c is not suitable to use alone for the diagnosis of GDM and is not useful in decreasing the need for OGT testing.
ISSN:0144-3615
1364-6893
DOI:10.3109/01443615.2014.925855