Impact of Studies of the Drosophila norpA Mutation on Understanding Phototransduction

Studies of the norpA mutation have significantly contributed to understanding the molecular and biochemical basis of phototransduction in Drosophila. Historical milestones in the study of the norpA mutation are reviewed and a contemporary model of the role of the NORPA protein in vision is presented...

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Bibliographic Details
Published in:Journal of neurogenetics 2012-06, Vol.26 (2), p.123-131
Main Author: Shortridge, Randall D.
Format: Article
Language:English
Subjects:
Animals
Drosophila
Drosophila - genetics
Drosophila Proteins - genetics
Light Signal Transduction - genetics
melanopsin
Mutation - genetics
phospholipase C
Phospholipase C beta - genetics
photoreceptor
rhabdomere
Second Messenger Systems - genetics
signalplex
vision
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Summary:Studies of the norpA mutation have significantly contributed to understanding the molecular and biochemical basis of phototransduction in Drosophila. Historical milestones in the study of the norpA mutation are reviewed and a contemporary model of the role of the NORPA protein in vision is presented. Questions awaiting further investigations are discussed.
ISSN:0167-7063
1563-5260
DOI:10.3109/01677063.2011.647142