Enhanced stability and in vitro bioactivity of surfactant-loaded liposomes containing Asiatic Pennywort extract

The objective of this work has been the microencapsulation of Asiatic Pennywort (AP) extract with lecithin from soybean. The effect of various quantities of non-ionic surfactant (Montanov82®) on liposomes upon physicochemical characteristics as well as their in vitro bio-activities was investigated....

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Bibliographic Details
Published in:Journal of microencapsulation 2010-08, Vol.27 (5), p.436-446
Main Authors: Saesoo, Somsak, Sramala, Issara, Soottitantawat, Apinan, Charinpanitkul, Tawatchai, Ruktanonchai, Uracha Rungsardthong
Format: Article
Language:English
Subjects:
Antioxidants - administration & dosage
Antioxidants - pharmacology
Asiatic pennywort
Biological and medical sciences
Cell Line
Cell Survival - drug effects
Centella - chemistry
Collagen - metabolism
Drug Compounding
Fibroblasts - drug effects
Fibroblasts - metabolism
General pharmacology
Glycine max - chemistry
Humans
Lecithins - chemistry
liposomes
Liposomes - chemistry
Medical sciences
Montanov82
non-ionic surfactant
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Surface-Active Agents
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Summary:The objective of this work has been the microencapsulation of Asiatic Pennywort (AP) extract with lecithin from soybean. The effect of various quantities of non-ionic surfactant (Montanov82®) on liposomes upon physicochemical characteristics as well as their in vitro bio-activities was investigated. An addition of surfactant resulted in a decrease in particle size and an increase in percentage AP entrapment efficiency of liposomes. The surfactant-loaded liposomes demonstrated higher stability than surfactant-free liposomes where higher percentage AP remaining of liposomes can be achieved depending on surfactant concentration. No significant difference was found on AP release profiles among varied surfactant concentrations, although a presence of surfactant resulted in prolonged AP release rate. Liposomal AP with 20% w/w surfactant or higher demonstrated low cytotoxicity, a stronger anti-oxidation effect and collagen production on dermal fibroblast cells when compared with free AP and surfactant-free liposomes, possibly due to better cell internalization and less AP degradation in cells.
ISSN:0265-2048
1464-5246
DOI:10.3109/02652040903447686