Preparation, characterisation and evaluation of curcumin with piperine-loaded cubosome nanoparticles

Abstract Objective: In this study, curcumin was designed into the nanoformulation called cubosome with piperine in order to improve oral bioavailability and tissue distribution of curcumin. Methods: The characteristic of the cubosome was studied by using scanning electron microscope (SEM), Infrared...

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Bibliographic Details
Published in:Journal of microencapsulation 2014-01, Vol.31 (6), p.551-559
Main Authors: Tu, Y. S., Fu, J. W., Sun, D. M., Zhang, J. J., Yao, N., Huang, D. E., Shi, Z. Q.
Format: Article
Language:English
Subjects:
Alkaloids - chemistry
Alkaloids - pharmacokinetics
Alkaloids - pharmacology
Animals
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Benzodioxoles - chemistry
Benzodioxoles - pharmacokinetics
Benzodioxoles - pharmacology
Bioavailability
cubosome
curcumin
Curcumin - chemistry
Curcumin - pharmacokinetics
Curcumin - pharmacology
Mice
Nanocapsules - chemistry
Particle Size
Piperidines - chemistry
Piperidines - pharmacokinetics
Piperidines - pharmacology
piperine
Polyunsaturated Alkamides - chemistry
Polyunsaturated Alkamides - pharmacokinetics
Polyunsaturated Alkamides - pharmacology
Scattering, Small Angle
Spleen - metabolism
Tissue Culture Techniques
X-Ray Diffraction
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Summary:Abstract Objective: In this study, curcumin was designed into the nanoformulation called cubosome with piperine in order to improve oral bioavailability and tissue distribution of curcumin. Methods: The characteristic of the cubosome was studied by using scanning electron microscope (SEM), Infrared spectrum and small angle X-ray scattering (SAXS) techniques. Tissue distribution of cubosome was measured by liquid chromatography-mass spectrometry (LC-MS) method in mice. Results: The characteristic of the cubosome was demonstrated that the curcumin and piperine were encapsulated in the interior of the cubosome and the crystal form was Pn3m space. The pharmacokinetic test revealed that the cubosome could improve the oral bioavailability significantly compared to the suspension of curcumin with piperine and be mainly absorbed by the spleen. Conclusion: These findings provide the reference to a preferable choice of the curcumin formulation and contribute to therapeutic application in clinical research.
ISSN:0265-2048
1464-5246
DOI:10.3109/02652048.2014.885607