Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury

Objective: To evaluate microtubule-associated proteins (MAP-2), a dendritic marker of both acute damage and chronic neuronal regeneration after injury, in serum of survivors after severe TBI and examine the association with long-term outcome. Methods: Serum concentrations of MAP-2 were evaluated in...

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Bibliographic Details
Published in:Brain injury 2012-12, Vol.26 (13-14), p.1629-1635
Main Authors: Mondello, Stefania, Gabrielli, Andrea, Catani, Sheila, D'Ippolito, Mariagrazia, Jeromin, Andreas, Ciaramella, Antonio, Bossù, Paola, Schmid, Kara, Tortella, Frank, Wang, Kevin K. W., Hayes, Ronald L., Formisano, Rita
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
biomarkers
Biomarkers - blood
Brain Injuries - blood
Brain Injuries - epidemiology
Brain Injuries - physiopathology
cognitive functioning
Disability Evaluation
Female
Follow-Up Studies
Glasgow Outcome Scale
Humans
Male
MAP2
Microtubule-Associated Proteins - blood
Middle Aged
outcome
Persistent Vegetative State - blood
Persistent Vegetative State - epidemiology
Persistent Vegetative State - physiopathology
Pilot Projects
Prognosis
Recovery of Function
Survivors
Time Factors
traumatic brain injury
United States - epidemiology
Young Adult
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Summary:Objective: To evaluate microtubule-associated proteins (MAP-2), a dendritic marker of both acute damage and chronic neuronal regeneration after injury, in serum of survivors after severe TBI and examine the association with long-term outcome. Methods: Serum concentrations of MAP-2 were evaluated in 16 patients with severe TBI (Glasgow Coma Scale score [GCS] ≤ 8) 6 months post-injury and in 16 controls. Physical and cognitive outcomes were assessed, using the Glasgow Outcome Scale Extended (GOSE) and Levels of Cognitive Functioning Scale (LCFS), respectively. Results: Severe TBI patients had significantly higher serum MAP-2 concentrations than normal controls with no history of TBI (p = 0.008) at 6 months post-injury. MAP-2 levels correlated with the GOSE (r = 0.58, p = 0.02) and LCFS (r = 0.65, p = 0.007) at month 6. Significantly lower serum levels of MAP-2 were observed in patients in a vegetative state (VS) compared to non-VS patients (p 
ISSN:0269-9052
1362-301X
DOI:10.3109/02699052.2012.700083