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Reversal of Intractable Acute Severe Asthma by First-Trimester Termination of Pregnancy
A 19-year-old woman was admitted with acute severe asthma in her eleventh week of pregnancy. Despite vigorous therapy, severe hypoventilation and hypoxemia persisted with mechanical ventilation. Termination of pregnancy resulted in dramatic improvement in airflow. Her course was complicated by pneum...
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| Published in: | The Journal of asthma 1997, Vol.34 (2), p.169-172 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c430t-16367530a2a4e19246a89527c77cd4d0ef155a1f3f7a02f09b56ec41cdcafd333 |
| container_end_page | 172 |
| container_issue | 2 |
| container_start_page | 169 |
| container_title | The Journal of asthma |
| container_volume | 34 |
| creator | Shaines, Harvey M. Venkataraman, Mythili T. Peter, Tessy |
| description | A 19-year-old woman was admitted with acute severe asthma in her eleventh week of pregnancy. Despite vigorous therapy, severe hypoventilation and hypoxemia persisted with mechanical ventilation. Termination of pregnancy resulted in dramatic improvement in airflow. Her course was complicated by pneumonia, barotrauma, and atelectasis accompanying her moribund state. Although she immediately improved following abortion (within 2 hr, peak airway pressure fell from >70 to 38 cmH2O, without change in plateau pressure), superimposed morbidities improved more slowly, and the patient made a complete recovery. The mechanism accounting for this observation is unknown but the rapid improvement following abortion suggests that increased bronchomotor tone predominated inflammatory changes in causing flow limitation. |
| doi_str_mv | 10.3109/02770909709075662 |
| format | article |
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Despite vigorous therapy, severe hypoventilation and hypoxemia persisted with mechanical ventilation. Termination of pregnancy resulted in dramatic improvement in airflow. Her course was complicated by pneumonia, barotrauma, and atelectasis accompanying her moribund state. Although she immediately improved following abortion (within 2 hr, peak airway pressure fell from >70 to 38 cmH2O, without change in plateau pressure), superimposed morbidities improved more slowly, and the patient made a complete recovery. The mechanism accounting for this observation is unknown but the rapid improvement following abortion suggests that increased bronchomotor tone predominated inflammatory changes in causing flow limitation.</description><identifier>ISSN: 0277-0903</identifier><identifier>EISSN: 1532-4303</identifier><identifier>DOI: 10.3109/02770909709075662</identifier><identifier>PMID: 9088304</identifier><identifier>CODEN: JOUADU</identifier><language>eng</language><publisher>New York, NY: Informa UK Ltd</publisher><subject>Abortion, Therapeutic ; Adult ; Anti-Bacterial Agents - therapeutic use ; Asthma ; Asthma - complications ; Asthma - therapy ; Barotrauma - complications ; Barotrauma - physiopathology ; Biological and medical sciences ; Diseases of mother, fetus and pregnancy ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Hypoventilation - complications ; Hypoventilation - therapy ; Hypoxia - complications ; Hypoxia - therapy ; Medical sciences ; Pneumonia, Bacterial - complications ; Pneumonia, Bacterial - drug therapy ; Pregnancy ; Pregnancy complications ; Pregnancy Complications - physiopathology ; Pregnancy Trimester, First ; Pregnancy. Fetus. Placenta ; Pulmonary Atelectasis - complications ; Pulmonary Atelectasis - physiopathology ; Respiration, Artificial - adverse effects</subject><ispartof>The Journal of asthma, 1997, Vol.34 (2), p.169-172</ispartof><rights>1997 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-16367530a2a4e19246a89527c77cd4d0ef155a1f3f7a02f09b56ec41cdcafd333</citedby><cites>FETCH-LOGICAL-c430t-16367530a2a4e19246a89527c77cd4d0ef155a1f3f7a02f09b56ec41cdcafd333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2628520$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9088304$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shaines, Harvey M.</creatorcontrib><creatorcontrib>Venkataraman, Mythili T.</creatorcontrib><creatorcontrib>Peter, Tessy</creatorcontrib><title>Reversal of Intractable Acute Severe Asthma by First-Trimester Termination of Pregnancy</title><title>The Journal of asthma</title><addtitle>J Asthma</addtitle><description>A 19-year-old woman was admitted with acute severe asthma in her eleventh week of pregnancy. Despite vigorous therapy, severe hypoventilation and hypoxemia persisted with mechanical ventilation. Termination of pregnancy resulted in dramatic improvement in airflow. Her course was complicated by pneumonia, barotrauma, and atelectasis accompanying her moribund state. Although she immediately improved following abortion (within 2 hr, peak airway pressure fell from >70 to 38 cmH2O, without change in plateau pressure), superimposed morbidities improved more slowly, and the patient made a complete recovery. The mechanism accounting for this observation is unknown but the rapid improvement following abortion suggests that increased bronchomotor tone predominated inflammatory changes in causing flow limitation.</description><subject>Abortion, Therapeutic</subject><subject>Adult</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Asthma</subject><subject>Asthma - complications</subject><subject>Asthma - therapy</subject><subject>Barotrauma - complications</subject><subject>Barotrauma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Hypoventilation - complications</subject><subject>Hypoventilation - therapy</subject><subject>Hypoxia - complications</subject><subject>Hypoxia - therapy</subject><subject>Medical sciences</subject><subject>Pneumonia, Bacterial - complications</subject><subject>Pneumonia, Bacterial - drug therapy</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Pregnancy Complications - physiopathology</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Pulmonary Atelectasis - complications</subject><subject>Pulmonary Atelectasis - physiopathology</subject><subject>Respiration, Artificial - adverse effects</subject><issn>0277-0903</issn><issn>1532-4303</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNp9UF1rFDEUDaLUbfUH-CDMg_g2epPMJBP0pRSrhUKLrvg43M3cuFNmJjXJWPbfN8NuCyL0JSE5H5xzGHvD4YPkYD6C0BoMmOXQtVLiGVvxWoqykiCfs9WClxmTL9lxjDcA-QPUETsy0DQSqhX79Z3-Uog4FN4VF1MKaBNuBipO7Zyo-LGg-RHTdsRisyvO-xBTuQ79SDFRKNYUxn7C1PtpcbgO9HvCye5esRcOh0ivD_cJ-3n-ZX32rby8-npxdnpZ2hwxlVxJpWsJKLAibkSlsDG10FZr21UdkON1jdxJpxGEA7OpFdmK286i66SUJ-z93vc2-D9zztSOfbQ0DDiRn2OrGwOVMiYT-Z5og48xkGtvcwkMu5ZDu4zZ_jdm1rw9mM-bkbpHxWG9jL874BgtDi7k5n18pAklmlpApn3e0_rJ-TDinQ9D1ybcDT48aORTKT79I98SDmlrMVB74-cw5Xmf6HAPN0ehCw</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Shaines, Harvey M.</creator><creator>Venkataraman, Mythili T.</creator><creator>Peter, Tessy</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Informa Healthcare</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Reversal of Intractable Acute Severe Asthma by First-Trimester Termination of Pregnancy</title><author>Shaines, Harvey M. ; Venkataraman, Mythili T. ; Peter, Tessy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-16367530a2a4e19246a89527c77cd4d0ef155a1f3f7a02f09b56ec41cdcafd333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Abortion, Therapeutic</topic><topic>Adult</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Asthma</topic><topic>Asthma - complications</topic><topic>Asthma - therapy</topic><topic>Barotrauma - complications</topic><topic>Barotrauma - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hypoventilation - complications</topic><topic>Hypoventilation - therapy</topic><topic>Hypoxia - complications</topic><topic>Hypoxia - therapy</topic><topic>Medical sciences</topic><topic>Pneumonia, Bacterial - complications</topic><topic>Pneumonia, Bacterial - drug therapy</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Pregnancy Complications - physiopathology</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Pulmonary Atelectasis - complications</topic><topic>Pulmonary Atelectasis - physiopathology</topic><topic>Respiration, Artificial - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shaines, Harvey M.</creatorcontrib><creatorcontrib>Venkataraman, Mythili T.</creatorcontrib><creatorcontrib>Peter, Tessy</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of asthma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shaines, Harvey M.</au><au>Venkataraman, Mythili T.</au><au>Peter, Tessy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reversal of Intractable Acute Severe Asthma by First-Trimester Termination of Pregnancy</atitle><jtitle>The Journal of asthma</jtitle><addtitle>J Asthma</addtitle><date>1997</date><risdate>1997</risdate><volume>34</volume><issue>2</issue><spage>169</spage><epage>172</epage><pages>169-172</pages><issn>0277-0903</issn><eissn>1532-4303</eissn><coden>JOUADU</coden><abstract>A 19-year-old woman was admitted with acute severe asthma in her eleventh week of pregnancy. Despite vigorous therapy, severe hypoventilation and hypoxemia persisted with mechanical ventilation. Termination of pregnancy resulted in dramatic improvement in airflow. Her course was complicated by pneumonia, barotrauma, and atelectasis accompanying her moribund state. Although she immediately improved following abortion (within 2 hr, peak airway pressure fell from >70 to 38 cmH2O, without change in plateau pressure), superimposed morbidities improved more slowly, and the patient made a complete recovery. The mechanism accounting for this observation is unknown but the rapid improvement following abortion suggests that increased bronchomotor tone predominated inflammatory changes in causing flow limitation.</abstract><cop>New York, NY</cop><pub>Informa UK Ltd</pub><pmid>9088304</pmid><doi>10.3109/02770909709075662</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0277-0903 |
| ispartof | The Journal of asthma, 1997, Vol.34 (2), p.169-172 |
| issn | 0277-0903 1532-4303 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_3109_02770909709075662 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Abortion, Therapeutic Adult Anti-Bacterial Agents - therapeutic use Asthma Asthma - complications Asthma - therapy Barotrauma - complications Barotrauma - physiopathology Biological and medical sciences Diseases of mother, fetus and pregnancy Female Gynecology. Andrology. Obstetrics Humans Hypoventilation - complications Hypoventilation - therapy Hypoxia - complications Hypoxia - therapy Medical sciences Pneumonia, Bacterial - complications Pneumonia, Bacterial - drug therapy Pregnancy Pregnancy complications Pregnancy Complications - physiopathology Pregnancy Trimester, First Pregnancy. Fetus. Placenta Pulmonary Atelectasis - complications Pulmonary Atelectasis - physiopathology Respiration, Artificial - adverse effects |
| title | Reversal of Intractable Acute Severe Asthma by First-Trimester Termination of Pregnancy |
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