In vitro percutaneous absorption of genistein from topical gels through human skin

The objective of this study was to formulate genistein as a topical gel with various penetration enhancers for increased permeation and retention in human skin. The high performance liquid chromatography assay method was validated for precision and reproducibility. The intra-day and inter-day precis...

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Bibliographic Details
Published in:Drug development and industrial pharmacy 2011-05, Vol.37 (5), p.498-505
Main Authors: Chadha, Gurkishan, Sathigari, Sateeshkumar, Parsons, Daniel L., Jayachandra Babu, R.
Format: Article
Language:English
Subjects:
Administration, Topical
Alcohols - chemistry
Blood pressure
Chemistry, Pharmaceutical - methods
Drug Delivery Systems - methods
gels
Gels - administration & dosage
Gels - chemistry
Gels - pharmacokinetics
genistein
Genistein - administration & dosage
Genistein - chemistry
Genistein - pharmacokinetics
human skin
Humans
Hydrogen-Ion Concentration
hypertension
Methylcellulose - chemistry
penetration enhancers
Permeability
Retention (Psychology)
Skin - metabolism
Skin Absorption
Terpenes - chemistry
topical
transdermal
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Summary:The objective of this study was to formulate genistein as a topical gel with various penetration enhancers for increased permeation and retention in human skin. The high performance liquid chromatography assay method was validated for precision and reproducibility. The intra-day and inter-day precision as represented by the coefficient of variation (CV) of the peak areas were
ISSN:0363-9045
1520-5762
DOI:10.3109/03639045.2010.525238