Daidzein/cyclodextrin/hydrophilic polymer ternary systems

Objective: To evaluate the effect of different cyclodextrins (β-cyclodextrin [β-CD], methyl-β-cyclodextrin [Mβ-CD], or hydroxypropyl-β-cyclodextrin [HPβ-CD]) and/or hydrophilic polymers (carboxymethylcellulose, hydroxypropylmethylcellulose [HPMC], polyethyleneglycol, or polyvinylpyrrolidone [PVP]) o...

Full description

Saved in:
Bibliographic Details
Published in:Drug development and industrial pharmacy 2011-08, Vol.37 (8), p.886-893
Main Authors: Borghetti, Greice Stefani, Pinto, Angela Pinheiro, Lula, Ivana Silva, Sinisterra, Rubén Dario, Teixeira, Helder Ferreira, Bassani, Valquiria Linck
Format: Article
Language:English
Subjects:
Chemistry, Pharmaceutical
Complexation
cyclodextrins
Cyclodextrins - chemistry
daidzein
hydrophilic polymers
Hydrophobic and Hydrophilic Interactions
Isoflavones - chemistry
Magnetic Resonance Spectroscopy - methods
Phytoestrogens - chemistry
Polymers - chemistry
Solubility
Water - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: To evaluate the effect of different cyclodextrins (β-cyclodextrin [β-CD], methyl-β-cyclodextrin [Mβ-CD], or hydroxypropyl-β-cyclodextrin [HPβ-CD]) and/or hydrophilic polymers (carboxymethylcellulose, hydroxypropylmethylcellulose [HPMC], polyethyleneglycol, or polyvinylpyrrolidone [PVP]) on daidzein solubility in water. Materials and methods: The corresponding associations were characterized in aqueous media using phase-solubility studies. The morphology of daidzein/cyclodextrin freeze-dried complexes was characterized using scanning electron microscopy, and their spatial configuration was proposed by means of nuclear magnetic resonance spectroscopy. Results and discussion: In the presence of 6 mM of cyclodextrins, the solubility of daidzein in water was significantly enhanced: 5.7-fold (β-CD), 7.2-fold (Mβ-CD), and 9.4-fold (HPβ-CD). The analysis of the three solid complexes proved that the formation of inclusion complexes occurred through the insertion of the B and C rings of daidzein molecule into the cyclodextrins cavity. The association of daidzein/cyclodextrin complexes to the hydrophilic polymers HPMC or PVP (1%, w/w) was able to improve the solubility of daidzein even further. Conclusion: The highest solubilizing effect was obtained for daidzein/HPβ-CD/PVP ternary system (12.7-fold).
ISSN:0363-9045
1520-5762
DOI:10.3109/03639045.2010.548066