Innovative approach to produce submicron drug particles by vibrational atomization spray drying: influence of the type of solvent and surfactant

Abstract Spray drying is a technique used to produce solid particles from liquid solutions, emulsions or suspensions. Buchi Labortechnik developed the latest generation of spray dryers, Nano Spray Dryer B-90. This study aims to obtain, directly, submicron drug particles from an organic solution, emp...

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Bibliographic Details
Published in:Drug development and industrial pharmacy 2014-08, Vol.40 (8), p.1011-1020
Main Authors: Durli, T. L., Dimer, F. A., Fontana, M. C., Pohlmann, A. R., Beck, R. C. R., Guterres, S. S.
Format: Article
Language:English
Subjects:
Dexamethasone
Dexamethasone - chemistry
Excipients - chemistry
ionic surfactants
Microscopy, Electron, Scanning - methods
Nano Spray Dryer
organic solution
Particle Size
Powders - chemistry
Solutions - chemistry
Solvents - chemistry
submicrometric particles
Surface Properties
Surface Tension
Surface-Active Agents - chemistry
Technology, Pharmaceutical - methods
vibrational atomization
Viscosity
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Summary:Abstract Spray drying is a technique used to produce solid particles from liquid solutions, emulsions or suspensions. Buchi Labortechnik developed the latest generation of spray dryers, Nano Spray Dryer B-90. This study aims to obtain, directly, submicron drug particles from an organic solution, employing this equipment and using dexamethasone as a model drug. In addition, we evaluated the influence of both the type of solvent and surfactant on the properties of the powders using a 32 full factorial analysis. The particles were obtained with high yields (above 60%), low water content (below 2%) and high drug content (above 80%). The surface tension and the viscosity were strongly influenced by the type of solvent. The highest powder yields were obtained for the highest surface tension and the lowest viscosity of the drug solutions. The use of ionic surfactants led to higher process yields. The laser diffraction technique revealed that the particles deagglomerate into small ones with submicrometric size, (around 1 µm) that was also observed by scanning electron microscopy. Interaction between the raw materials in the spray-dried powders was verified by calorimetric analysis. Thus, it was possible to obtain dexamethasone submicrometric particles by vibrational atomization from organic solution.
ISSN:0363-9045
1520-5762
DOI:10.3109/03639045.2013.798804