Formulation Development of Oral Controlled-Release Pellets of Diclofenac Sodium

Abstract In this study, various formulations of controlled-release pellets of diclofenac sodium were prepared. Selected polymeric film coatings were applied to the drug-loaded nonpareils and their effects on the in vitro drug release from the multiple-unit dosage form were examined. It was found tha...

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Bibliographic Details
Published in:Drug development and industrial pharmacy 1997, Vol.23 (10), p.1013-1017
Main Authors: Wang, Da-Peng, Yang, Ming-Chang, Wong, Chi-Yin
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
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Summary:Abstract In this study, various formulations of controlled-release pellets of diclofenac sodium were prepared. Selected polymeric film coatings were applied to the drug-loaded nonpareils and their effects on the in vitro drug release from the multiple-unit dosage form were examined. It was found that a combination of ethylcellulose, myvacet 9-40, and talc produced a stable film coating and controlled drug release was achieved. Dissolution data demonstrated that this formulation produced predictable and reproducible drug data release characteristics.
ISSN:0363-9045
1520-5762
DOI:10.3109/03639049709149155