Association of Functionally Important Polymorphism of Microsomal Epoxide Hydrolase Gene (EPHX1) With Lung Cancer Susceptibility

Distribution and gene-environment interaction of EPHX1 polymorphism was evaluated in 175 lung cancer patients and 322 controls from north India. Two novel non-synonymous, Lys117Arg and Leu263Phe, and twelve single nucleotide polymorphisms were identified in the present study. Binary logistic regress...

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Bibliographic Details
Published in:Cancer investigation 2011-07, Vol.29 (6), p.411-418
Main Authors: Tilak, Anup R., Kumar, Sachin, Jain, Meenu, Pant, Mohan C., Das, Bhudev C., Guleria, Randeep, Mittal, Balraj, Mathur, Neeraj, Kumar, Ashwani
Format: Article
Language:English
Subjects:
Adult
Aged
EPHX1
Epoxide Hydrolases - genetics
Female
Genetic Predisposition to Disease
Humans
India
Logistic Models
Lung cancer
Lung Neoplasms - etiology
Lung Neoplasms - genetics
Male
Middle Aged
Polymorphism, Genetic
Single nucleotide polymorphism (SNP)
Smoking - adverse effects
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Summary:Distribution and gene-environment interaction of EPHX1 polymorphism was evaluated in 175 lung cancer patients and 322 controls from north India. Two novel non-synonymous, Lys117Arg and Leu263Phe, and twelve single nucleotide polymorphisms were identified in the present study. Binary logistic regression analysis showed association of polymorphism Tyr113His with increased risk of lung cancer (OR = 2.2, 95% CI = 1.2-4.0, p < .05). Gene-environment interaction revealed that patients with His113His and smoking habit had significantly greater risk of lung cancer (OR = 4.52, 95% CI = 0.93-43.05, p < .05). Present study provided evidence that EPHX1 polymorphism is associated with lung cancer susceptibility in Indian population.
ISSN:0735-7907
1532-4192
DOI:10.3109/07357907.2011.587070