Roles and Mechanisms of β-Thymosins in Cell Migration and Cancer Metastasis: An Update

β-thymosins, including thymosin β4 (Tβ4), Tβ10, and Tβ15, are a family of highly conserved 5 kDa peptides. They are involved not only in normal cell migration, but also in tumor metastasis. However, the molecular mechanisms of β-thymosins to regulate cell migration and other functions are not fully...

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Bibliographic Details
Published in:Cancer investigation 2013-02, Vol.31 (2), p.103-110
Main Authors: Sribenja, Sirinapa, Wongkham, Sopit, Wongkham, Chaisiri, Yao, Qizhi, Chen, Changyi
Format: Article
Language:English
Subjects:
Actin-sequestering
Actins - metabolism
Animals
Antineoplastic agents
Biological and medical sciences
Cancer Metastasis
Cell Movement - physiology
Epithelial-Mesenchymal Transition
Epithelial-to-mesenchymal Transition
Humans
Medical sciences
Migration
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplasm Metastasis
Neoplasms - metabolism
Neoplasms - pathology
Pharmacology. Drug treatments
Thymosin - chemistry
Thymosin - metabolism
Thymosin β10
Thymosin β4
Tumors
β-Thymosins
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Summary:β-thymosins, including thymosin β4 (Tβ4), Tβ10, and Tβ15, are a family of highly conserved 5 kDa peptides. They are involved not only in normal cell migration, but also in tumor metastasis. However, the molecular mechanisms of β-thymosins to regulate cell migration and other functions are not fully understood. Recently, this important area is under active investigation worldwide. Many new discoveries have been made from molecular biology and cell culture models as well as animal models and human diseases. This timely review provides the most updated information about functional roles and molecular mechanisms of β-thymosins in normal tissues and disease conditions.
ISSN:0735-7907
1532-4192
DOI:10.3109/07357907.2012.756111