Glioma-Derived Thrombospondin-1 Modulates Cd14+ Cell Tolerogenic Properties

Thrombospondin-1 (TSP1) plays a role in the immune tolerance, and is involved in the pathogenesis of glioma. This study aims to investigate the role of the glioma-derived TSP1 in the induction of the tumor immune tolerance. The results showed that the primary human glioma cells expressed high levels...

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Bibliographic Details
Published in:Cancer investigation 2015-04, Vol.33 (4), p.152-157
Main Authors: Ma, Yuan, Qu, Bo, Xia, Xun, Yang, Libin, Kuang, Yongqin, Yang, Tao, Cheng, Jingmin, Sun, Haodong, Fan, Kexia, Gu, Jianwen
Format: Article
Language:English
Subjects:
Adult
Female
Glioma
Glioma - chemistry
Glioma - immunology
Humans
Immune Tolerance
Lipopolysaccharide Receptors - analysis
Male
Middle Aged
Monocytes
Monocytes - immunology
Thrombospondin 1 - analysis
Thrombospondin 1 - physiology
Thrombospondin-1
Transforming Growth Factor beta - analysis
Transforming growth factor-β
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Summary:Thrombospondin-1 (TSP1) plays a role in the immune tolerance, and is involved in the pathogenesis of glioma. This study aims to investigate the role of the glioma-derived TSP1 in the induction of the tumor immune tolerance. The results showed that the primary human glioma cells expressed high levels of TSP1. Glioma cells enhanced the expression of transforming growth factor (TGF)-β in CD4+ CD16− naïve monocytes (Mos). The TGF-β+ Mos showed inhibitory effect on CD8+ T cell proliferation. We conclude that glioma cell-derived TSP1 facilitates the induction of TGF-β in Mos. The TSP1 may be a potential therapeutic target of glioma.
ISSN:0735-7907
1532-4192
DOI:10.3109/07357907.2015.1010089