Distribution and functional significance of angiotensin-II AT1-AND AT2-Receptor subtypes in the rat adrenal gland

The distribution and the functional significance of angiotensin-II (ANG-II) receptor subtypes. AT1 and AT2, in the rat adrenal gland has been investigated in vitro Autoradiographic assessment of the selective displacement of [125I]ANG-II binding by selective ligands of the two receptor subtypes indi...

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Bibliographic Details
Published in:Endocrine research 1998-01, Vol.24 (1), p.1-15
Main Authors: Belloni, Anna S., Andreis, Paola G., Macchi, Veronica, Gottardo, Giuseppe, Malendowicz, Ludwick K., Nussdorfer, Gastone G.
Format: Article
Language:English
Subjects:
Adrenal Glands - drug effects
Adrenal Glands - metabolism
Adrenal Glands - secretion
Aldosterone - secretion
Angiotensin II - analysis
Angiotensin II - metabolism
Angiotensin Receptor Antagonists
Animals
Antihypertensive Agents - pharmacology
Autoradiography
Catecholamines - secretion
Imidazoles - pharmacology
Iodine Radioisotopes
Losartan - pharmacology
Male
Oligopeptides - pharmacology
Osmolar Concentration
Pyridines - pharmacology
Rats
Rats, Wistar
Receptor, Angiotensin, Type 1
Receptor, Angiotensin, Type 2
Receptors, Angiotensin - analysis
Receptors, Angiotensin - metabolism
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Summary:The distribution and the functional significance of angiotensin-II (ANG-II) receptor subtypes. AT1 and AT2, in the rat adrenal gland has been investigated in vitro Autoradiographic assessment of the selective displacement of [125I]ANG-II binding by selective ligands of the two receptor subtypes indicated that zona glomerulosa (ZG) was provided with both AT1 and AT2, and adrenal medulla (AM) almost exclusively with AT2 receptors ANG-II (10−9 M) evoked a marked rise in the secretion of aldosterone by dispersed ZG cells and catecholamines by AM fragments The selective AT1-receptor antagonist DuP753 blocked aldosterone response to ANG-II, while the selective AT2-receptor antagonist PD123319 was ineffective. Catecholamine response to ANG-II was inhibited by PD123319 and only moderately affected by high concentrations of DuP753. The selective AT2-receptor agonist CGP42112 did not change basal aldosterone release of ZG cells, but concentration-dependently enhanced basal catecholamine release by AM fragments. In light of these findings the conclusion is drawn that in the rat the aldosterone secretagogue effect of ANG-II is exclusively mediated by the AT1 receptors present in the ZG, while the catecholamine secretagogue action preminently involves the activation of AT2 receptor located on medullary chromaffin cells
ISSN:0743-5800
1532-4206
DOI:10.3109/07435809809031865