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Distribution and functional significance of angiotensin-II AT1-AND AT2-Receptor subtypes in the rat adrenal gland
The distribution and the functional significance of angiotensin-II (ANG-II) receptor subtypes. AT1 and AT2, in the rat adrenal gland has been investigated in vitro Autoradiographic assessment of the selective displacement of [125I]ANG-II binding by selective ligands of the two receptor subtypes indi...
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| Published in: | Endocrine research 1998-01, Vol.24 (1), p.1-15 |
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| container_title | Endocrine research |
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| creator | Belloni, Anna S. Andreis, Paola G. Macchi, Veronica Gottardo, Giuseppe Malendowicz, Ludwick K. Nussdorfer, Gastone G. |
| description | The distribution and the functional significance of angiotensin-II (ANG-II) receptor subtypes. AT1 and AT2, in the rat adrenal gland has been investigated in vitro Autoradiographic assessment of the selective displacement of [125I]ANG-II binding by selective ligands of the two receptor subtypes indicated that zona glomerulosa (ZG) was provided with both AT1 and AT2, and adrenal medulla (AM) almost exclusively with AT2 receptors ANG-II (10−9 M) evoked a marked rise in the secretion of aldosterone by dispersed ZG cells and catecholamines by AM fragments The selective AT1-receptor antagonist DuP753 blocked aldosterone response to ANG-II, while the selective AT2-receptor antagonist PD123319 was ineffective. Catecholamine response to ANG-II was inhibited by PD123319 and only moderately affected by high concentrations of DuP753. The selective AT2-receptor agonist CGP42112 did not change basal aldosterone release of ZG cells, but concentration-dependently enhanced basal catecholamine release by AM fragments. In light of these findings the conclusion is drawn that in the rat the aldosterone secretagogue effect of ANG-II is exclusively mediated by the AT1 receptors present in the ZG, while the catecholamine secretagogue action preminently involves the activation of AT2 receptor located on medullary chromaffin cells |
| doi_str_mv | 10.3109/07435809809031865 |
| format | article |
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AT1 and AT2, in the rat adrenal gland has been investigated in vitro Autoradiographic assessment of the selective displacement of [125I]ANG-II binding by selective ligands of the two receptor subtypes indicated that zona glomerulosa (ZG) was provided with both AT1 and AT2, and adrenal medulla (AM) almost exclusively with AT2 receptors ANG-II (10−9 M) evoked a marked rise in the secretion of aldosterone by dispersed ZG cells and catecholamines by AM fragments The selective AT1-receptor antagonist DuP753 blocked aldosterone response to ANG-II, while the selective AT2-receptor antagonist PD123319 was ineffective. Catecholamine response to ANG-II was inhibited by PD123319 and only moderately affected by high concentrations of DuP753. The selective AT2-receptor agonist CGP42112 did not change basal aldosterone release of ZG cells, but concentration-dependently enhanced basal catecholamine release by AM fragments. 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AT1 and AT2, in the rat adrenal gland has been investigated in vitro Autoradiographic assessment of the selective displacement of [125I]ANG-II binding by selective ligands of the two receptor subtypes indicated that zona glomerulosa (ZG) was provided with both AT1 and AT2, and adrenal medulla (AM) almost exclusively with AT2 receptors ANG-II (10−9 M) evoked a marked rise in the secretion of aldosterone by dispersed ZG cells and catecholamines by AM fragments The selective AT1-receptor antagonist DuP753 blocked aldosterone response to ANG-II, while the selective AT2-receptor antagonist PD123319 was ineffective. Catecholamine response to ANG-II was inhibited by PD123319 and only moderately affected by high concentrations of DuP753. The selective AT2-receptor agonist CGP42112 did not change basal aldosterone release of ZG cells, but concentration-dependently enhanced basal catecholamine release by AM fragments. In light of these findings the conclusion is drawn that in the rat the aldosterone secretagogue effect of ANG-II is exclusively mediated by the AT1 receptors present in the ZG, while the catecholamine secretagogue action preminently involves the activation of AT2 receptor located on medullary chromaffin cells</description><subject>Adrenal Glands - drug effects</subject><subject>Adrenal Glands - metabolism</subject><subject>Adrenal Glands - secretion</subject><subject>Aldosterone - secretion</subject><subject>Angiotensin II - analysis</subject><subject>Angiotensin II - metabolism</subject><subject>Angiotensin Receptor Antagonists</subject><subject>Animals</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Autoradiography</subject><subject>Catecholamines - secretion</subject><subject>Imidazoles - pharmacology</subject><subject>Iodine Radioisotopes</subject><subject>Losartan - pharmacology</subject><subject>Male</subject><subject>Oligopeptides - pharmacology</subject><subject>Osmolar Concentration</subject><subject>Pyridines - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptor, Angiotensin, Type 1</subject><subject>Receptor, Angiotensin, Type 2</subject><subject>Receptors, Angiotensin - analysis</subject><subject>Receptors, Angiotensin - metabolism</subject><issn>0743-5800</issn><issn>1532-4206</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNp9kEtrGzEQx0VpSZ2kH6CHgk69baKRdtdr2ovJ0xBaKMl50WNkK6wlR9IS_O2rxaZQSgqCQfwfM_wI-QzsQgBbXLJ5LZqOLcpjArq2eUdm0Ahe1Zy178ls0qtiYB_JaUrPjIFgTJyQk0XTiHkDM_Jy7VKOTo3ZBU-lN9SOXk8fOdDk1t5Zp6XXSIMt8tqFjD45X61WdPkI1fLHdZm8-oUadzlEmkaV9ztM1HmaN0ijzFSaiFPfeigLzskHK4eEn47zjDzd3jxe3VcPP-9WV8uHStcMcqXq2jSgwXStkYqDxgYkIEiNmnNuFYqaLUApsFrPWymRGei0MVzVTCEXZ-TroXcXw8uIKfdblzQO5QYMY-rnhVpXt6wY4WDUMaQU0fa76LYy7ntg_YS5_wdzyXw5lo9qi-ZP4si16N8PuvM2xK18DXEwfZb7IUQbC0-Xpuq367_9Fd-gHPJGy4j9cxhjYZn-c9xvB6eenw</recordid><startdate>19980101</startdate><enddate>19980101</enddate><creator>Belloni, Anna S.</creator><creator>Andreis, Paola G.</creator><creator>Macchi, Veronica</creator><creator>Gottardo, Giuseppe</creator><creator>Malendowicz, Ludwick K.</creator><creator>Nussdorfer, Gastone G.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980101</creationdate><title>Distribution and functional significance of angiotensin-II AT1-AND AT2-Receptor subtypes in the rat adrenal gland</title><author>Belloni, Anna S. ; Andreis, Paola G. ; Macchi, Veronica ; Gottardo, Giuseppe ; Malendowicz, Ludwick K. ; Nussdorfer, Gastone G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-b44d51c1d86dab21ce51a1e1acec222fbe34091bb1fcc76aae0d18cdd2b40be23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adrenal Glands - drug effects</topic><topic>Adrenal Glands - metabolism</topic><topic>Adrenal Glands - secretion</topic><topic>Aldosterone - secretion</topic><topic>Angiotensin II - analysis</topic><topic>Angiotensin II - metabolism</topic><topic>Angiotensin Receptor Antagonists</topic><topic>Animals</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Autoradiography</topic><topic>Catecholamines - secretion</topic><topic>Imidazoles - pharmacology</topic><topic>Iodine Radioisotopes</topic><topic>Losartan - pharmacology</topic><topic>Male</topic><topic>Oligopeptides - pharmacology</topic><topic>Osmolar Concentration</topic><topic>Pyridines - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptor, Angiotensin, Type 1</topic><topic>Receptor, Angiotensin, Type 2</topic><topic>Receptors, Angiotensin - analysis</topic><topic>Receptors, Angiotensin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belloni, Anna S.</creatorcontrib><creatorcontrib>Andreis, Paola G.</creatorcontrib><creatorcontrib>Macchi, Veronica</creatorcontrib><creatorcontrib>Gottardo, Giuseppe</creatorcontrib><creatorcontrib>Malendowicz, Ludwick K.</creatorcontrib><creatorcontrib>Nussdorfer, Gastone G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belloni, Anna S.</au><au>Andreis, Paola G.</au><au>Macchi, Veronica</au><au>Gottardo, Giuseppe</au><au>Malendowicz, Ludwick K.</au><au>Nussdorfer, Gastone G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution and functional significance of angiotensin-II AT1-AND AT2-Receptor subtypes in the rat adrenal gland</atitle><jtitle>Endocrine research</jtitle><addtitle>Endocr Res</addtitle><date>1998-01-01</date><risdate>1998</risdate><volume>24</volume><issue>1</issue><spage>1</spage><epage>15</epage><pages>1-15</pages><issn>0743-5800</issn><eissn>1532-4206</eissn><abstract>The distribution and the functional significance of angiotensin-II (ANG-II) receptor subtypes. AT1 and AT2, in the rat adrenal gland has been investigated in vitro Autoradiographic assessment of the selective displacement of [125I]ANG-II binding by selective ligands of the two receptor subtypes indicated that zona glomerulosa (ZG) was provided with both AT1 and AT2, and adrenal medulla (AM) almost exclusively with AT2 receptors ANG-II (10−9 M) evoked a marked rise in the secretion of aldosterone by dispersed ZG cells and catecholamines by AM fragments The selective AT1-receptor antagonist DuP753 blocked aldosterone response to ANG-II, while the selective AT2-receptor antagonist PD123319 was ineffective. Catecholamine response to ANG-II was inhibited by PD123319 and only moderately affected by high concentrations of DuP753. The selective AT2-receptor agonist CGP42112 did not change basal aldosterone release of ZG cells, but concentration-dependently enhanced basal catecholamine release by AM fragments. In light of these findings the conclusion is drawn that in the rat the aldosterone secretagogue effect of ANG-II is exclusively mediated by the AT1 receptors present in the ZG, while the catecholamine secretagogue action preminently involves the activation of AT2 receptor located on medullary chromaffin cells</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>9553751</pmid><doi>10.3109/07435809809031865</doi><tpages>15</tpages></addata></record> |
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| ispartof | Endocrine research, 1998-01, Vol.24 (1), p.1-15 |
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| language | eng |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Adrenal Glands - drug effects Adrenal Glands - metabolism Adrenal Glands - secretion Aldosterone - secretion Angiotensin II - analysis Angiotensin II - metabolism Angiotensin Receptor Antagonists Animals Antihypertensive Agents - pharmacology Autoradiography Catecholamines - secretion Imidazoles - pharmacology Iodine Radioisotopes Losartan - pharmacology Male Oligopeptides - pharmacology Osmolar Concentration Pyridines - pharmacology Rats Rats, Wistar Receptor, Angiotensin, Type 1 Receptor, Angiotensin, Type 2 Receptors, Angiotensin - analysis Receptors, Angiotensin - metabolism |
| title | Distribution and functional significance of angiotensin-II AT1-AND AT2-Receptor subtypes in the rat adrenal gland |
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