Six-channel ECG-based pulse wave velocity for assessing whole-body arterial stiffness

Abstract Background. Despite the proposal of different means of non-invasive arterial stiffness assessment, none offers simultaneous information on whole-body peripheral arterial condition. We investigated the validity of applying a six-channel electrocardiogram-based pulse wave velocity (ECG-PWV) m...

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Bibliographic Details
Published in:Blood pressure 2012-06, Vol.21 (3), p.167-176
Main Authors: Wu, Hsien-Tsai, Hsu, Po-Chun, Liu, An-Bang, Chen, Zong-Li, Huang, Ruay-Ming, Chen, Ching-Pin, Tang, Chieh-Ju, Sun, Cheuk-Kwan
Format: Article
Language:English
Subjects:
atherosclerosis
Blood Flow Velocity
Carotid Arteries - diagnostic imaging
Carotid Arteries - physiopathology
Carotid Intima-Media Thickness - instrumentation
diabetes
Electrocardiography - methods
Female
Humans
hypertension
intima-media thickness
Male
Middle Aged
peripheral arterial stiffness
Pulsatile Flow
pulse wave velocity
Vascular Stiffness
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Summary:Abstract Background. Despite the proposal of different means of non-invasive arterial stiffness assessment, none offers simultaneous information on whole-body peripheral arterial condition. We investigated the validity of applying a six-channel electrocardiogram-based pulse wave velocity (ECG-PWV) measurement system for this purpose. Methods. The study consisted of two parts. Part One enrolled hypertensive (Group 1, n = 32) and normal (Group 2, n = 32) subjects, whereas Part Two recruited diabetic (Group 3, n = 50) and normal (Group 4, n = 50) subjects. To validate the application of ECG-PWV in assessing peripheral arterial stiffness in different parts of body, ECG-PWV data were compared with three other parameters including the cardio-ankle vascular index (CAVI), pulse wave velocity-digital volume pulse (PWV-DVP) and intima-media thickness (IMT). Results. ECG-PWV in healthy subjects in Part One correlated significantly with CAVI and PWV-DVP (p
ISSN:0803-7051
1651-1999
DOI:10.3109/08037051.2012.681853