Hemorrheological Indices, Catecholamines, Neuropeptide Y and Serotonin in Patients with Essential Hypertension

• Published in: Blood pressure 1997, Vol.6 (4), p.203-208
• Main Authors: Berent, Hanna, Kuczy ska, Krystyna, Kochma ski, Marek, Wocial, Bo Ena, api ski, Mariusz, Lewandowski, Jacek, Januszewicz, Andeuej, Ignatowska- witalska, Hanna, Januszewicz, W odzimierz
• Format: Article
• Language: English
• Subjects: Adult; Arterial hypertension. Arterial hypotension; beta-Thromboglobulin - metabolism; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Epinephrine - blood; Erythrocyte Aggregation; Female; Fibrinogen - metabolism; Hematocrit; Humans; hypertension; Hypertension - blood; Male; Medical sciences; Middle Aged; Neuropeptide Y - blood; Norepinephrine - blood; Platelet Aggregation; platelets; Rheology; Serotonin - blood; Sex Factors; sympathoadrenal system
• ISSN: 0803-7051; 1651-1999
• DOI: 10.3109/08037059709062070

Berent H, Kuczy skov K, Kochma ski M, Wocial B, api ski M, Lewandowski J, Januszewicz A, Igantowska- witalska H, Wlodzimierz J, Hemorrheological indices, catecholamines, neuropeptide Y and serotonin in patients with essential hypertension. Hemorrheological and humoral abnormalities and excessive platelet activity can predict the development of cardiovascular complications in patients with essential hypertension. A study was conducted to assess the influence of gender on these factors and the interrelations between changes in hemorrheology and the sympathoadrenal system in 54 patients (18 women, 36 men) with essential hypertension (aged 39.6 ± 9.7 years) and 25 healthy volunteers (10 women, 15 men; aged 36.0 ± 7.2 years). A decrease in erythrocyte deformability (p < 0.01) was found in the hypertensive men compared with the hypertensive women. Hematocrit (p < 0.01), blood viscosity at the shear rates of 0.3s−1(p < 0.01) and 6s-1(p < 0.01), plasma viscosity (p < 0.01), erythrocyte aggregation (p < 0.01), and neuropeptide Y (p < 0.02) concentrations were higher in the hypertensive men than in the hypertensive women. A positive correlation between blood fibrinogen and serotonin was found in the pooled hypertensive group and in the hypertensive men (p < 0.01) and between blood viscosity (shear rate 6s-1) and neuropeptide Y in the pooled hypertensive group (p < 0.01). Neuropeptide Y correlated with filtration time of 1 mL blood in the hypertensive men (p < 0.05) and in the pooled normotensive group (p < 0.01) and with β-thromboglobulin in the hypertensive women (p < 0.001). A positive correlation was also found in the hypertensive men between erythrocyte and platelet aggregation (p < 0.01) and between β-thromboglobulin and adrenaline (p < 0.01). Hemorrheological and humoral abnormalities are more pronounced in men than in women with essential hypertension and may contribute to the increased incidence of cardiovascular events in men.