Soluble (s) CD14 and Plasmatic Lipopolysaccharides (LPS) in Patients with Chronic Hepatitis C Before and After Treatment with Interferon (IFN)-α

Abstract CD14 is a monocyte/polymorphonuclear cell receptor for lipopolysaccharide (LPS)-LPS Binding Protein (LBP), which mediates most of the toxic effects exerted by such a bacterial component in the host. Here, we provide evidence that sCD14 and interferon (IFN)-γ serum levels are significantly h...

Full description

Saved in:
Bibliographic Details
Published in:Immunopharmacology and immunotoxicology 1998-01, Vol.20 (1), p.1-14
Main Authors: Jirillo, Emilio, Amati, Luigi, Caradonna, Luigi, Greco, Beatrice, Cozzolongo, Raffaele, Cuppone, Renato, Piazzolla, Giuseppina, Caccavo, Domenico, Antonaci, Salvatore, Manghisi, Onofrio G.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Female
Hepatitis C, Chronic - blood
Hepatitis C, Chronic - drug therapy
Humans
Immunomodulators
Interferon-alpha - therapeutic use
Lipopolysaccharide Receptors - blood
Lipopolysaccharides - blood
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
T-Lymphocytes - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract CD14 is a monocyte/polymorphonuclear cell receptor for lipopolysaccharide (LPS)-LPS Binding Protein (LBP), which mediates most of the toxic effects exerted by such a bacterial component in the host. Here, we provide evidence that sCD14 and interferon (IFN)-γ serum levels are significantly higher in chronic hepatitis C (CH-C) patients than those detected in normal donors. On the other hand, CD4+/CD8+ antibacterial activity is depressed, thus facilitating entry of bacteria into the host. Of note, all these immune parameters are not modified by in vivo IFN-α administration over a period of one year. Finally, after 12 months of IFN-α treatment number of CH-C patients with detectable levels of plasmatic LPS increased, thus indicating a continuous release of LPS into the host and also suggesting a putative pathogenetic role for sCD14 LPS-LBP complex in subjects affected by CH-C virus infection.
ISSN:0892-3973
1532-2513
DOI:10.3109/08923979809034805