Correlation between plasminogen activator inhibitor-1 (PAI-1) promoter 4G/5G polymorphism and metabolic/proinflammatory factors in polycystic ovary syndrome

• Published in: Gynecological endocrinology 2013-10, Vol.29 (10), p.936-939
• Main Authors: Sales, MF, Sóter, MO, Candido, AL, Fernandes, AP, Oliveira, FR, Ferreira, ACS, Sousa, MO, Ferreira, CN, Gomes, KB
• Format: Article
• Language: English
• Subjects: Adult; Body Mass Index; Cardiovascular Diseases - etiology; Case-Control Studies; Female; Genetic Association Studies; Humans; Inflammation Mediators - blood; LAP; PAI-1; Plasminogen Activator Inhibitor 1 - genetics; polycystic ovary syndrome; Polycystic Ovary Syndrome - complications; Polycystic Ovary Syndrome - genetics; Polycystic Ovary Syndrome - metabolism; Polymorphism, Genetic; Promoter Regions, Genetic; Risk Factors; VCAM; vitamin D; Young Adult
• ISSN: 0951-3590; 1473-0766
• DOI: 10.3109/09513590.2013.819086

Abstract Polycystic Ovary Syndrome (PCOS) is the most common cause of subfertility associated to metabolic disorders. The aim of this study was to correlate metabolic and proinflammatory factors in women with PCOS. The frequency of Plasminogen Activator Inhibitor-1 (PAI-1) promoter 4 G/5 G polymorphism was also compared to healthy controls. We evaluated 79 PCOS and 79 healthy women. PAI-1 levels are positively correlated with proinflammatory factors in PCOS group. 4 G allele in PAI-1 gene was more frequent in PCOS and the 4G/4 G genotype was associated with increased PAI-1 levels. A correlation between insulin resistance and proinflammatory and overweight was also observed. C-reactive protein, serum levels of vascular cell adhesion molecule-1 (sVCAM-1), Lipid Accumulation Product (LAP) and vitamin D are good tools to evaluated factors associated to cardiovascular risk in women with PCOS.