Platelet activation in chronic cocaine users: Effect of short term abstinence

Cocaine abuse increases the risk of cardiac and cerebrovascular events, such as myocardial infarction and ischemic stroke. The underlying mechanisms leading to these complications are not fully understood although intravascular thrombus formation has been observed. The aim of this study was to inves...

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Bibliographic Details
Published in:Platelets (Edinburgh) 2011-12, Vol.22 (8), p.596-601
Main Authors: Pereira, Jaime, Sáez, Claudia G., Pallavicini, Julio, Panes, Olga, Pereira-Flores, Karla, Cabreras, Manuel J., Massardo, Teresa, Mezzano, Diego
Format: Article
Language:English
Subjects:
Adult
atherosclrosis
beta-Thromboglobulin - metabolism
Biomarkers - blood
CD40 Ligand - blood
Cell Aggregation - drug effects
cocaine
Cocaine - pharmacology
Cocaine-Related Disorders - blood
Cocaine-Related Disorders - metabolism
Female
Humans
Male
Middle Aged
Monocytes - drug effects
Monocytes - metabolism
platelet activation
Platelet Activation - drug effects
Platelet Aggregation - drug effects
platelet chemokines
Young Adult
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Summary:Cocaine abuse increases the risk of cardiac and cerebrovascular events, such as myocardial infarction and ischemic stroke. The underlying mechanisms leading to these complications are not fully understood although intravascular thrombus formation has been observed. The aim of this study was to investigate the existence of platelet activation and the effect of short-term abstinence in chronic cocaine consumers. We studied 23 cocaine dependent individuals (aged 20-54 years) who met DSM-IV criteria for cocaine dependence and 20 controls. Samples were obtained at baseline, within 72 h of last drug exposure and after 4 weeks of controlled abstinence. Monocyte-platelet aggregates (MPA) were measured by flow cytometry. Plasma levels of soluble CD40L (sCD40L), Neutrophil-Activating Peptide-2 (NAP-2) and regulated on activation normal T cells expressed and secreted (RANTES) were determined by ELISA. Levels of MPA, sCD40L, NAP-2 and RANTES were significantly higher (all p 
ISSN:0953-7104
1369-1635
DOI:10.3109/09537104.2011.578181