Platelet and mean platelet volume kinetics in adult patients with sepsis

Abstract The aims of this study were to evaluate the kinetics of platelet counts and mean platelet volume (MPV) in adults with sepsis and to determine whether the responses are infection-specific. This retrospective cohort study included patients admitted to a tertiary-care teaching hospital with mi...

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Bibliographic Details
Published in:Platelets (Edinburgh) 2015-01, Vol.26 (4), p.331-335
Main Authors: Aydemir, Hande, Piskin, Nihal, Akduman, Deniz, Kokturk, Furuzan, Aktas, Elif
Format: Article
Language:English
Subjects:
Aged
Blood Platelets - immunology
Cohort Studies
Female
Humans
Male
Mean platelet volume
Mean Platelet Volume - methods
Middle Aged
platelet count
Retrospective Studies
sepsis
Sepsis - blood
thrombocytopenia
Thrombocytopenia - immunology
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Summary:Abstract The aims of this study were to evaluate the kinetics of platelet counts and mean platelet volume (MPV) in adults with sepsis and to determine whether the responses are infection-specific. This retrospective cohort study included patients admitted to a tertiary-care teaching hospital with microbiologically proven nosocomial sepsis between January 2006 and January 2011. Platelet counts and MPV measurements were examined daily for 5 days after the onset of sepsis. During the study period, 151 of the 214 sepsis episodes were associated with thrombocytopenia. Gram-positive microorganisms were the most frequently isolated. The decrease in platelet counts was statistically significant for the first 3 days of sepsis in Gram-positive septic patients, for 4 days in Gram-negative septic patients and for all 5 days in fungal septic patients (p 
ISSN:0953-7104
1369-1635
DOI:10.3109/09537104.2012.701027