The role of IL-17 in psoriasis

Abstract Background: Psoriasis is a chronic skin condition traditionally believed to involve the Th1 pathway. Recently, the IL-23/Th17/IL-17 pathway has been highlighted in the pathogenesis of psoriasis and other autoimmune inflammatory conditions. From a clinician's perspective, we sought to r...

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Bibliographic Details
Published in:The Journal of dermatological treatment 2015-02, Vol.26 (1), p.41-44
Main Authors: Malakouti, Mona, Brown, Gabrielle Elena, Wang, Eva, Koo, John, Levin, Ethan C.
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal, Humanized - pharmacology
Biologics
brodalumab
Cytokines - immunology
Humans
Interleukin-17 - antagonists & inhibitors
Interleukin-17 - immunology
Interleukin-22
Interleukin-23 - immunology
Interleukins - immunology
Ixekizumab
Mice
Psoriasis - drug therapy
Psoriasis - immunology
secukinumab
Th17
Th17 Cells - immunology
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Summary:Abstract Background: Psoriasis is a chronic skin condition traditionally believed to involve the Th1 pathway. Recently, the IL-23/Th17/IL-17 pathway has been highlighted in the pathogenesis of psoriasis and other autoimmune inflammatory conditions. From a clinician's perspective, we sought to review the basic science data relevant to IL-17's role in psoriasis pathogenesis. Methods: We performed a Pubmed and Web of Knowledge search for English articles starting from 1990 that discussed the Th17 pathway. Search terms such as "IL-17" and "psoriasis" were utilized. Results: The IL-17 pathway is regulated by IL-23, a cytokine that is vital for the expansion and maintenance of the Th17 cell population. Th17 derived cytokines (IL-17A, IL-17F, IL-17A/F and IL-22) were elevated in both psoriasis-like murine models and human psoriatic lesional biopsies. Ixekizumab (anti-IL-17A) treatment of psoriasis was found to normalize levels of IL-17 downstream gene products. Conclusion: Both preclinical and clinical studies support the central role of IL-17 in the pathogenesis of psoriasis.
ISSN:0954-6634
1471-1753
DOI:10.3109/09546634.2013.879093