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The role of IL-17 in psoriasis
Abstract Background: Psoriasis is a chronic skin condition traditionally believed to involve the Th1 pathway. Recently, the IL-23/Th17/IL-17 pathway has been highlighted in the pathogenesis of psoriasis and other autoimmune inflammatory conditions. From a clinician's perspective, we sought to r...
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| Published in: | The Journal of dermatological treatment 2015-02, Vol.26 (1), p.41-44 |
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| Main Authors: | , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c418t-5af25785e668b4731ecbba4e0da6035d313525ee238f0067790152ec9248cd733 |
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| cites | cdi_FETCH-LOGICAL-c418t-5af25785e668b4731ecbba4e0da6035d313525ee238f0067790152ec9248cd733 |
| container_end_page | 44 |
| container_issue | 1 |
| container_start_page | 41 |
| container_title | The Journal of dermatological treatment |
| container_volume | 26 |
| creator | Malakouti, Mona Brown, Gabrielle Elena Wang, Eva Koo, John Levin, Ethan C. |
| description | Abstract
Background: Psoriasis is a chronic skin condition traditionally believed to involve the Th1 pathway. Recently, the IL-23/Th17/IL-17 pathway has been highlighted in the pathogenesis of psoriasis and other autoimmune inflammatory conditions. From a clinician's perspective, we sought to review the basic science data relevant to IL-17's role in psoriasis pathogenesis.
Methods: We performed a Pubmed and Web of Knowledge search for English articles starting from 1990 that discussed the Th17 pathway. Search terms such as "IL-17" and "psoriasis" were utilized.
Results: The IL-17 pathway is regulated by IL-23, a cytokine that is vital for the expansion and maintenance of the Th17 cell population. Th17 derived cytokines (IL-17A, IL-17F, IL-17A/F and IL-22) were elevated in both psoriasis-like murine models and human psoriatic lesional biopsies. Ixekizumab (anti-IL-17A) treatment of psoriasis was found to normalize levels of IL-17 downstream gene products.
Conclusion: Both preclinical and clinical studies support the central role of IL-17 in the pathogenesis of psoriasis. |
| doi_str_mv | 10.3109/09546634.2013.879093 |
| format | article |
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Background: Psoriasis is a chronic skin condition traditionally believed to involve the Th1 pathway. Recently, the IL-23/Th17/IL-17 pathway has been highlighted in the pathogenesis of psoriasis and other autoimmune inflammatory conditions. From a clinician's perspective, we sought to review the basic science data relevant to IL-17's role in psoriasis pathogenesis.
Methods: We performed a Pubmed and Web of Knowledge search for English articles starting from 1990 that discussed the Th17 pathway. Search terms such as "IL-17" and "psoriasis" were utilized.
Results: The IL-17 pathway is regulated by IL-23, a cytokine that is vital for the expansion and maintenance of the Th17 cell population. Th17 derived cytokines (IL-17A, IL-17F, IL-17A/F and IL-22) were elevated in both psoriasis-like murine models and human psoriatic lesional biopsies. Ixekizumab (anti-IL-17A) treatment of psoriasis was found to normalize levels of IL-17 downstream gene products.
Conclusion: Both preclinical and clinical studies support the central role of IL-17 in the pathogenesis of psoriasis.</description><identifier>ISSN: 0954-6634</identifier><identifier>EISSN: 1471-1753</identifier><identifier>DOI: 10.3109/09546634.2013.879093</identifier><identifier>PMID: 24552504</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Animals ; Antibodies, Monoclonal, Humanized - pharmacology ; Biologics ; brodalumab ; Cytokines - immunology ; Humans ; Interleukin-17 - antagonists & inhibitors ; Interleukin-17 - immunology ; Interleukin-22 ; Interleukin-23 - immunology ; Interleukins - immunology ; Ixekizumab ; Mice ; Psoriasis - drug therapy ; Psoriasis - immunology ; secukinumab ; Th17 ; Th17 Cells - immunology</subject><ispartof>The Journal of dermatological treatment, 2015-02, Vol.26 (1), p.41-44</ispartof><rights>2014 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-5af25785e668b4731ecbba4e0da6035d313525ee238f0067790152ec9248cd733</citedby><cites>FETCH-LOGICAL-c418t-5af25785e668b4731ecbba4e0da6035d313525ee238f0067790152ec9248cd733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24552504$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Malakouti, Mona</creatorcontrib><creatorcontrib>Brown, Gabrielle Elena</creatorcontrib><creatorcontrib>Wang, Eva</creatorcontrib><creatorcontrib>Koo, John</creatorcontrib><creatorcontrib>Levin, Ethan C.</creatorcontrib><title>The role of IL-17 in psoriasis</title><title>The Journal of dermatological treatment</title><addtitle>J Dermatolog Treat</addtitle><description>Abstract
Background: Psoriasis is a chronic skin condition traditionally believed to involve the Th1 pathway. Recently, the IL-23/Th17/IL-17 pathway has been highlighted in the pathogenesis of psoriasis and other autoimmune inflammatory conditions. From a clinician's perspective, we sought to review the basic science data relevant to IL-17's role in psoriasis pathogenesis.
Methods: We performed a Pubmed and Web of Knowledge search for English articles starting from 1990 that discussed the Th17 pathway. Search terms such as "IL-17" and "psoriasis" were utilized.
Results: The IL-17 pathway is regulated by IL-23, a cytokine that is vital for the expansion and maintenance of the Th17 cell population. Th17 derived cytokines (IL-17A, IL-17F, IL-17A/F and IL-22) were elevated in both psoriasis-like murine models and human psoriatic lesional biopsies. Ixekizumab (anti-IL-17A) treatment of psoriasis was found to normalize levels of IL-17 downstream gene products.
Conclusion: Both preclinical and clinical studies support the central role of IL-17 in the pathogenesis of psoriasis.</description><subject>Animals</subject><subject>Antibodies, Monoclonal, Humanized - pharmacology</subject><subject>Biologics</subject><subject>brodalumab</subject><subject>Cytokines - immunology</subject><subject>Humans</subject><subject>Interleukin-17 - antagonists & inhibitors</subject><subject>Interleukin-17 - immunology</subject><subject>Interleukin-22</subject><subject>Interleukin-23 - immunology</subject><subject>Interleukins - immunology</subject><subject>Ixekizumab</subject><subject>Mice</subject><subject>Psoriasis - drug therapy</subject><subject>Psoriasis - immunology</subject><subject>secukinumab</subject><subject>Th17</subject><subject>Th17 Cells - immunology</subject><issn>0954-6634</issn><issn>1471-1753</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLw0AUhQdRbK3-AylZukmdyTySbBQpPgoFN3U9TCY3dEqSqTMJ0n_vhLSCm67u5jvnXD6E7gleUILzR5xzJgRliwQTusjSHOf0Ak0JS0lMUk4v0XRA4oGZoBvvdziAAmfXaJIwzhOO2RTNN1uInK0hslW0WodkZNpo760zyht_i64qVXu4O94Z-np73Sw_4vXn-2r5so41I1kXc1UlPM04CJEVLKUEdFEoBrhUAlNeUkLDHkBCswpjkYZnCU9A5wnLdJlSOkMPY-_e2e8efCcb4zXUtWrB9l4SIQgNLWxA2YhqZ713UMm9M41yB0mwHMzIkxk5mJGjmRCbHxf6ooHyL3RSEYDnETBtZV2jfqyrS9mpQ21d5VSrjR_qz048_WvYgqq7rVYO5M72rg0Cz__4CwirgaI</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Malakouti, Mona</creator><creator>Brown, Gabrielle Elena</creator><creator>Wang, Eva</creator><creator>Koo, John</creator><creator>Levin, Ethan C.</creator><general>Informa UK Ltd</general><general>Informa Healthcare</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150201</creationdate><title>The role of IL-17 in psoriasis</title><author>Malakouti, Mona ; Brown, Gabrielle Elena ; Wang, Eva ; Koo, John ; Levin, Ethan C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-5af25785e668b4731ecbba4e0da6035d313525ee238f0067790152ec9248cd733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal, Humanized - pharmacology</topic><topic>Biologics</topic><topic>brodalumab</topic><topic>Cytokines - immunology</topic><topic>Humans</topic><topic>Interleukin-17 - antagonists & inhibitors</topic><topic>Interleukin-17 - immunology</topic><topic>Interleukin-22</topic><topic>Interleukin-23 - immunology</topic><topic>Interleukins - immunology</topic><topic>Ixekizumab</topic><topic>Mice</topic><topic>Psoriasis - drug therapy</topic><topic>Psoriasis - immunology</topic><topic>secukinumab</topic><topic>Th17</topic><topic>Th17 Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malakouti, Mona</creatorcontrib><creatorcontrib>Brown, Gabrielle Elena</creatorcontrib><creatorcontrib>Wang, Eva</creatorcontrib><creatorcontrib>Koo, John</creatorcontrib><creatorcontrib>Levin, Ethan C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of dermatological treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malakouti, Mona</au><au>Brown, Gabrielle Elena</au><au>Wang, Eva</au><au>Koo, John</au><au>Levin, Ethan C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of IL-17 in psoriasis</atitle><jtitle>The Journal of dermatological treatment</jtitle><addtitle>J Dermatolog Treat</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>26</volume><issue>1</issue><spage>41</spage><epage>44</epage><pages>41-44</pages><issn>0954-6634</issn><eissn>1471-1753</eissn><abstract>Abstract
Background: Psoriasis is a chronic skin condition traditionally believed to involve the Th1 pathway. Recently, the IL-23/Th17/IL-17 pathway has been highlighted in the pathogenesis of psoriasis and other autoimmune inflammatory conditions. From a clinician's perspective, we sought to review the basic science data relevant to IL-17's role in psoriasis pathogenesis.
Methods: We performed a Pubmed and Web of Knowledge search for English articles starting from 1990 that discussed the Th17 pathway. Search terms such as "IL-17" and "psoriasis" were utilized.
Results: The IL-17 pathway is regulated by IL-23, a cytokine that is vital for the expansion and maintenance of the Th17 cell population. Th17 derived cytokines (IL-17A, IL-17F, IL-17A/F and IL-22) were elevated in both psoriasis-like murine models and human psoriatic lesional biopsies. Ixekizumab (anti-IL-17A) treatment of psoriasis was found to normalize levels of IL-17 downstream gene products.
Conclusion: Both preclinical and clinical studies support the central role of IL-17 in the pathogenesis of psoriasis.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>24552504</pmid><doi>10.3109/09546634.2013.879093</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0954-6634 |
| ispartof | The Journal of dermatological treatment, 2015-02, Vol.26 (1), p.41-44 |
| issn | 0954-6634 1471-1753 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_3109_09546634_2013_879093 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Animals Antibodies, Monoclonal, Humanized - pharmacology Biologics brodalumab Cytokines - immunology Humans Interleukin-17 - antagonists & inhibitors Interleukin-17 - immunology Interleukin-22 Interleukin-23 - immunology Interleukins - immunology Ixekizumab Mice Psoriasis - drug therapy Psoriasis - immunology secukinumab Th17 Th17 Cells - immunology |
| title | The role of IL-17 in psoriasis |
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